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Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain
(2012)
Chronic pain is associated with cognitive deficits. Considerable overlap in brain regions involved in pain and aversion suggests that aversive learning and memory may be affected during chronic pain. Passive-avoidance ...
The endocannabinoid system and emotional processing: pathophysiology and therapeutic potential.
(SAGE, 2012-01)
Although the pharmacological and medicinal properties of the plant Cannabis sativa have long been known and appreciated, the discovery of the endocannabinoid system began with the isolation of [delta]9-tetrahydrocannabinol ...
Behavioural, neurochemical and neuroendocrine effects of the endogenous beta-carboline harmane in fear-conditioned rats
(2012)
The putative endogenous imidazoline binding site ligand harmane enhances neuronal activation in response to psychological stress and alters behaviour in animal models of anxiety and antidepressant efficacy. However, the ...
Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats
(Elsevier, 2012-12-31)
The basolateral amygdala (BLA) is a key substrate facilitating the expression of fear-conditioned analgesia (FCA). However, the neurochemical mechanisms in the BLA which mediate this potent suppression of pain responding ...