Browsing Pharmacology & Therapeutics (Scholarly Articles) by Author "College of Science, National University of Ireland, Galway"
Now showing items 1-3 of 3
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Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey
Madasu, Manish K.; Okine, Bright N.; Olango, Weredeselam M.; Rea, Kieran; Lenihan, Róisín; Roche, Michelle; Finn, David P. (Elsevier, 2016-08-09)Negative affective state has a significant impact on pain, and genetic background is an important moderating influence on this interaction. The Wistar-Kyoto (WKY) inbred rat strain exhibits a stress-hyperresponsive, ... -
N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism
Okine, Bright N.; Madasu, Manish K.; McGowan, Fiona; Prendergast, Charles; Gaspar, Jessica C.; Harhen, Brendan; Roche, Michelle; Finn, David P. (Lippincott, Williams & Wilkins, 2016-12)The neural substrates and mechanisms mediating the antinociceptive effects of the endogenous bioactive lipid, N-palmitoylethanolamide (PEA), require further investigation. We investigated the effects of exogenous PEA ... -
Supraspinal Transient Receptor Potential Subfamily V Member 1 (TRPV1) in pain and psychiatric disorders
Madasu, Manish K.; Roche, Michelle; Finn, David P. (Karger, 2015)The transient receptor potential subfamily V member 1 (TRPV1) belongs to the diverse transient receptor potential (TRP) family of cation channels. It was first characterized in primary afferent fibres as a receptor for ...