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    Author
    Roche, Michelle (32)
    Finn, David P. (31)Harhen, Brendan (8)Okine, Bright N. (8)Kelly, John P. (7)... View MoreSubjectPain (10)c-Fos (4)Endocannabinoid (4)Fear (4)INFLAMMATORY PAIN (4)... View MoreDate Issued2010 - 2020 (29)2007 - 2009 (3)TypeArticle (28)Book chapter (3)Conference Paper (1)

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    Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate 

    Rea, Kieran; Roche, Michelle; Finn, David P. (2007)
    Recent physiological, pharmacological and anatomical studies provide evidence that one of the main roles of the endocannabinoid system in the brain is the regulation of ¿-aminobutyric acid (GABA) and glutamate release. ...
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    Pharmacological inhibition of monoacylglycerol lipase attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action 

    Kerr, Danny; Harhen, Brendan; Egan, Jonathan; Finn, David P.; Roche, Michelle (2013)
    Background and purpose: This study determined the effect of JZL184, a selective inhibitor of monoacylglycerol lipase (MAGL), the enzyme which preferentially catabolises the endocannabinoid 2-arachidonoyl glycerol (2-AG), ...
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    The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nocicpetive tone 

    Olango, W.M.; Roche, Michelle; Ford, Gemma K.; Harhen, Brendan; Finn, David P. (Wiley, 2011)
    Background and purpose: Endocannabinoids in the midbrain periaqueductal grey (PAG) are involved in modulating nociception and unconditioned stress-induced analgesia, however, their role in fear-conditioned analgesia (FCA) ...
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    Fear-induced suppression of nociceptive behaviour and activation of signal transduction molecules in the rat periaqueductal grey: role of fatty acid amide hydrolase. 

    Butler, Ryan K.; Ford, Gemma K.; Hogan, Michelle; Roche, Michelle; Doyle, Karen M.; Kelly, John P.; Finn, David P. (Sage, 2011-09-17)
    The endocannabinoid system regulates nociception and aversion and mediates fear-conditioned analgesia (FCA). We investigated the effects of the fatty acid amide hydrolase (FAAH) inhibitor URB597, which inhibits the catabolism ...
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    Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions 

    Burke, N.N.; Hayes, E; Calpin, P; Kerr, DM; Moriarty, Orla; Finn, David P.; Roche, Michelle (2010)
    Altered pain responding in depression is a widely recognized but poorly understood phenomenon The present study investigated nociceptive responding to acute (thermal and mechanical) and persistent (inflammatory) noxious ...
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    Brain CB2 receptors: Implication for Neuropsychiatric disorders 

    Roche, Michelle; Finn, David P. (2010)
    Although previously thought of as the peripheral cannabinoid receptor, it is now accepted that the CB2 receptor is expressed in the central nervous system on microglia, astrocytes and subpopulations of neurons. Expression ...
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    Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomised rat 

    Roche, Michelle; Harkin, Andrew; Kelly, John P. (2007)
    The olfactory bulbectomized (OB) rat is a well characterized animal model that exhibits a number of behavioural and neurochemical changes that have relevance to clinical depression. Hyperactivity in the open field is the ...
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    Development and characterization of a novel, anatomically relevant rat model of acute postoperative pain 

    Bree, Dara; Moriarty, Orla; O’Mahony, Cliona M.; Morris, Bradley; Bannerton, Karen; Broom, Daniel C.; Kelly, John P.; Roche, Michelle; Finn, David P. (Elsevier, 2015-01-30)
    Acute postoperative pain remains a significant health care issue. Development of anatomically relevant animal models of postoperative pain, with improved predictive validity, would advance understanding of postoperative ...
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    6-iodonordihydrocapsaicin 

    Roche, Michelle; Finn, David P. (2009)
    6-Iodonordihydrocapsaicin was first synthesized by Giovanni Appendino at the Department of Chemical, Food, Pharmaceutical and Pharmacological Sciences (DiSCAFF), Novara, Italy, while developing a series of halogenated ...
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    Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor 

    Kerr, D.M.; Burke, N.N.; Ford, Gemma K.; Harhen, Brendan; Egan, Laurence J.; Finn, David P.; Roche, Michelle (Elsevier, 2011-09)
    The endocannabinoid system is an important regulator of the nervous, neuroendocrine, and immune systems, thus representing a novel therapeutic target for stress-related neuroinflammatory and psychiatric disorders. However, ...
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