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Hyporesponsivity to mu-opioid receptor agonism in the Wistar-Kyoto rat model of altered nociceptive responding associated with negative affective state.

Ferdousi, Mehnaz I.; Calcagno, Patricia; Clarke, Morgane; Aggarwal, Sonali; Sanchez, Connie; Smith, Karen L.; Eyerman, David J.; Kelly, John P.; Roche, Michelle; Finn, David P. (Lippincott, Williams & Wilkins, 2020-08-17)

Chronic pain is often comorbid with anxiety and depression, altering the level of perceived pain, which negatively affects therapeutic outcomes. The role of the endogenous mu-opioid receptor (MOP) system in pain-negative ...