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Maternal deprivation is associated with sex-dependent alterations in nociceptive behavior and neuroinflammatory mediators in the rat following peripheral nerve injury
(Elsevier, 2013-10)
Early-life stress is associated with an increased risk of developing affective disorders and chronic pain conditions. This study examined the effect of maternal deprivation (MD) on nociceptive responding prior to and ...
Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala
(Wiley, 2013-08-29)
The association between chronic pain and depression is widely recognized, the comorbidity of which leads to a heavier disease burden, increased disability and poor treatment response. This study examined nociceptive ...
Regulating immunogenicity and tolerogenicity of bone marrow-derived dendritic cells through modulation of cell surface glycosylation by dexamethasone treatment
(Frontiers Media, 2017-10-30)
Dendritic cellular therapies and dendritic cell vaccines show promise for the treatment of autoimmune diseases, the prolongation of graft survival in transplantation, and in educating the immune system to fight cancers. ...
Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype
(Elsevier, 2015-02)
Chronic pain and depression share a complex, reciprocal relationship. Furthermore, in addition to treating depression, antidepressants such as amitriptyline are a first-line treatment for chronic pain conditions, indicating ...
Using qualitative insights to change practice: exploring the culture of antibiotic prescribing and consumption for urinary tract infections
(BMJ Publishing Group, 2016-01-11)
Objectives: The aim of this paper is to explore the culture of antibiotic prescribing and consumption in the community for urinary tract infections (UTI) from the perspective of the general practitioners (GPs) and community ...
Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies
(PeerJ, 2016-08-30)
Cellular therapies, with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and for the prevention of destructive immune responses after transplantation The methodologies ...
Teaching and learning through civic engagement: prospects for sustainability in teacher education
(2010)
This paper considers the prospects for sustainable service/community based learning as an element of a civic engagement strategy within the context of teacher education. It
draws on findings of a study of the policy, ...
Mesenchymal stem cell therapy to promote corneal allograft survival: current status and pathway to clinical translation
(Lippincott, Williams & Wilkins, 2016-12)
PURPOSE OF REVIEW: This article reviews the literature on the therapeutic potential of mesenchymal stem cells (MSCs) to prolong corneal allograft survival.
RECENT FINDINGS: To date, only small numbers studies have ...
Exploring experiences of delayed prescribing and symptomatic treatment for urinary tract infections among general practitioners and patients in ambulatory care: a qualitative study
(MDPI (Multidisciplinary Digital Publishing Institute), 2016-08-15)
"Delayed or back up" antibiotic prescriptions and "symptomatic" treatment may help to reduce inappropriate antibiotic prescribing for Urinary Tract Infections (UTI) in the future. However, more research needs to be conducted ...
Free water elimination and mapping from diffusion tensor imaging (DTI) in chronic schizophrenia
(NUI Galway, 2017-06-11)
Diffusion tensor imaging (DTI) acquisitions allows the comparison of diffusion characteristics in vivo and gives a unique insight into tissue structure and pathology. However, a limitation of DTI post-processing is the ...