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Maternal deprivation is associated with sex-dependent alterations in nociceptive behavior and neuroinflammatory mediators in the rat following peripheral nerve injury
(Elsevier, 2013-10)
Early-life stress is associated with an increased risk of developing affective disorders and chronic pain conditions. This study examined the effect of maternal deprivation (MD) on nociceptive responding prior to and ...
Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala
(Wiley, 2013-08-29)
The association between chronic pain and depression is widely recognized, the comorbidity of which leads to a heavier disease burden, increased disability and poor treatment response. This study examined nociceptive ...
Anandamide modulation of endotoxin-induced inflammation
(OMICS International, 2013-12-20)
The endocannabinoid system is comprised of the CB1
and CB2
receptors, the naturally occurring endogenous ligands, anandamide
(AEA) and 2-arachidonyl glycerol (2-AG); and the enzymes
involved in their synthesis and ...
miR-379 Regulates Cyclin B1 Expression and Is Decreased in Breast Cancer
(2013)
MicroRNAs are small non-coding RNA molecules that control gene expression post-transcriptionally, and are known
to be altered in many diseases including breast cancer. The aim of this study was to determine the relevance ...
Pharmacological inhibition of monoacylglycerol lipase attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action
(2013)
Background and purpose: This study determined the effect of JZL184, a selective inhibitor of monoacylglycerol lipase (MAGL), the enzyme which preferentially catabolises the endocannabinoid 2-arachidonoyl glycerol (2-AG), ...
Gender-specific abnormalities in the serotonin transporter system in panic disorder
(Cambridge University Press, 2013)
The central serotonergic system has been implicated in the pathophysiology of panic disorder (PD) by evidence of abnormally elevated serotonin-turnover, reduced pre- and post-synaptic 5-HT(1A-)receptor sensitivity and ...
Curriculum development for sustainable civic engagement
(Educational Developers of Ireland Network, 2013)
Capacity building
both for students and for community partners is an explicit goal for one
particular teaching and learning innovation in Irish higher education. In
addition to offering the opportunity to apply ...
The 5-HT1A receptor and 5-HT transporter in temporal lobe epilepsy
(2013)
Objective: To study 5-HT transport and 5-HT1A receptors in temporal lobe epilepsy (TLE) and depression.Methods: Thirteen patients had PET with [C-11]DASB for 5-HTT and [F-18]FCWAY for 5-HT1A receptor binding, MRI, and ...
An evaluation of MyAction, a community-based lifestyle and medical risk factor modification programme, in women with prior gestational diabetes mellitus: study protocol for a randomised controlled trial
(BioMed Central, 2013-05-02)
Universal screening using the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria has identified a prevalence of gestational diabetes mellitus (GDM) of 12.4% in women living in Ireland. Women ...
Surgical checklists: the human factor
(2013)
Surgical checklists has been shown to improve patient safety and teamwork in the operating theatre. However, despite the known benefits of the use of checklists in surgery, in some cases the practical implementation has ...