Browsing School of Medicine by Author "Sanchez, Connie"
Now showing items 1-4 of 4
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Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats
Burke, Nikita N.; Li, Yan; Daniel R Deaver, Daniel R.; Deaver, Daniel R.; Finn, David P.; Roche, Michelle; Eyerman, David J.; Sanchez, Connie; Kelly, John P. (SAGE Publications, 2019-09-12)Background: The combination of buprenorphine, a partial mu-opioid receptor agonist and a functional kappa-opioid receptor antagonist, with samidorphan, a functional mu-opioid receptor antagonist, is being developed as an ... -
Hyporesponsivity to mu-opioid receptor agonism in the Wistar-Kyoto rat model of altered nociceptive responding associated with negative affective state.
Ferdousi, Mehnaz I.; Calcagno, Patricia; Clarke, Morgane; Aggarwal, Sonali; Sanchez, Connie; Smith, Karen L.; Eyerman, David J.; Kelly, John P.; Roche, Michelle; Finn, David P. (Lippincott, Williams & Wilkins, 2020-08-17)Chronic pain is often comorbid with anxiety and depression, altering the level of perceived pain, which negatively affects therapeutic outcomes. The role of the endogenous mu-opioid receptor (MOP) system in pain-negative ... -
Kappa opioid receptor-mediated modulation of social responding in adolescent rats and in rats prenatally exposed to valproic acid
Hughes, Edel M.; Thornton, Aoife M.; Kerr, Daniel M.; Smith, Karen; Sanchez, Connie; Kelly, John P.; Finn, David P. (Elsevier, 2020-08-05)The kappa opioid receptor (KOP) system modulates social play responding, however a paucity of studies have examined effects on social motivation and cognition in the absence of play. Prenatal exposure to the anti epileptic ... -
Prenatal exposure to valproic acid reduces social responses and alters mRNA levels of opioid receptor and pre-pro-peptide in discrete brain regions of adolescent and adult male rats
Hughes, Edel M.; Calcagno, Patricia; Clarke, Morgane; Sanchez, Connie; Smith, Karen; Kelly, John P.; Finn, David P.; Roche, Michelle (Elsevier, 2020-01-21)Altered social behaviours are a hallmark of several psychiatric and developmental disorders. Clinical and preclinical data have demonstrated that prenatal exposure to valproic acid (VPA), an anti-epileptic and mood stabiliser, ...