Browsing School of Medicine by Author "O’Brien, Timothy"

Now showing items 1-3 of 3

    • Effect of cyclosporin A on functional recovery in the spinal cord following contusion injury 

      McMahon, Siobhan S.; Albermann, Silke; Rooney, Gemma E.; Moran, Cathal; Hynes, Jacqueline; Garcia, Yolanda; Dockery, Peter; O’Brien, Timothy; Windebank, Anthony J.; Barry, Frank P. (Wiley, 2009-08-20)
      Considerable evidence has shown that the immunosuppressant drug cyclosporin A (CsA) may have neuroprotective properties which can be exploited in the treatment of spinal cord injury. The aim of this study was to investigate ...

    • Impact of mesenchymal stem cell secreted PAI-1 on colon cancer cell migration and proliferation 

      Hogan, Niamh M.; Joyce, Myles R.; Murphy, J. Mary; Barry, Frank P.; O’Brien, Timothy; Kerin, Michael J.; Dwyer, Róisín M. (Elsevier, 2013-05-16)
      Mesenchymal Stem Cells are known to engraft and integrate into the architecture of colorectal tumours, with little known regarding their fate following engraftment. This study aimed to investigate mediators of Mesenchymal ...

    • Ulk4 regulates GABAergic signaling and anxiety-related behavior 

      Liu, Min; Fitzgibbon, Marie; Wang, Yanqin; Reilly, Jamie; Qian, Xiaohong; O’Brien, Timothy; Clapcote, Steve; Shen, Sanbing; Roche, Michelle (Springer Nature, 2018-02-02)
      Excitation/inhibition imbalance has been proposed as a fundamental mechanism in the pathogenesis of neuropsychiatric and neurodevelopmental disorders, in which copy number variations of the Unc-51 like kinase 4 (ULK4) gene ...