Now showing items 1-3 of 3

    • Endocannabinoid modulation of inflammatory hyperalgesia in the IFN-α mouse model of depression 

      Fitzgibbon, Marie; Kerr, Daniel M.; Henry, Rebecca J.; Finn, David P.; Roche, Michelle (Elsevier, 2019-09-07)
      Depression is a well-recognised effect of long-term treatment with interferon-alpha (IFN-alpha), a widely used treatment for chronic viral hepatitis and malignancy. In addition to the emotional disturbances, high incidences ...
    • High times for painful blues: the endocannabinoid system in pain-depression comorbidity 

      Fitzgibbon, Marie; Finn, David P.; Roche, Michelle (Oxford University Press (OUP), 2015-09-05)
      Depression and pain are two of the most debilitating disorders worldwide and have an estimated cooccurrence of up to 80%. Comorbidity of these disorders is more difficult to treat, associated with significant disability ...
    • Ulk4 regulates GABAergic signaling and anxiety-related behavior 

      Liu, Min; Fitzgibbon, Marie; Wang, Yanqin; Reilly, Jamie; Qian, Xiaohong; O’Brien, Timothy; Clapcote, Steve; Shen, Sanbing; Roche, Michelle (Springer Nature, 2018-02-02)
      Excitation/inhibition imbalance has been proposed as a fundamental mechanism in the pathogenesis of neuropsychiatric and neurodevelopmental disorders, in which copy number variations of the Unc-51 like kinase 4 (ULK4) gene ...