Browsing School of Medicine by Author "Doyle, Karen M."
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Acute ischemic stroke secondary to cardiac embolus of a ‘foreign body’ material after a redo sternotomy for mitral valve replacement: A case report
Fitzgerald, Seán; Rizvi, Asim; Dai, Daying; Williamson, Eric E.; Lanzino, Giuseppe; Doyle, Karen M.; Kallmes, David F.; Brinjikji, Waleed (SAGE Publications, 2018-11-14)Cardiac surgery has been shown to be associated with increased risk of acute ischemic stroke. This report presents a case of a successful mechanical embolectomy procedure to treat a patient for an acute ischemic stroke, ... -
The administration of rtPA before mechanical thrombectomy in acute ischemic stroke patients is associated with a significant reduction of the retrieved clot area but it does not influence revascularization outcome
Rossi, Rosanna; Fitzgerald, Sean; Molina, Sara; Mereuta, Oana Madalina; Douglas, Andrew; Pandit, Abhay; Santos, Andreia M. Silva; Murphy, Blathnaid; Alderson, Jack; Brennan, Paul; Power, Sarah; O'Hare, Alan; Gilvarry, Michael; McCarthy, Ray; Psychogios, Klearchos; Magoufis, Georgios; Tsivgoulis, Georgios; Nagy, Andras; Vadasz, Agnes; Szikora, Istvan; Jood, Katarina; Redfors, Petra; Nordanstig, Annika; Ceder, Erik; Dehlfors, Niclas; Dunker, Dennis; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen M. (Springer, 2020-09-16)Both intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) are evidence-based treatments for acute ischemic stroke (AIS) in selected cases. Recanalization may occur following IVT without the necessity of further ... -
Animal models of focal cerebral ischaemia and haemorrhage transformation: considerations in experimental stroke study design
Shearer, J. Andrew; Douglas, Andrew S.; Kirby, B. P.; Tatlisumak, Turgut; Doyle, Karen M. (Bentham Science Publishers, 2017)Background: Ischaemic stroke is often complicated with haemorrhage within the infarct zone or in a remote location especially when treated with intravenous thrombolysis and/or thrombectomy. While these early recanalisation ... -
Dielectric profile of blood clots to inform ischemic stroke treatments
Santorelli, Adam; Fitzgerald, Seán; Douglas, Andrew; Doyle, Karen M.; O’Halloran, Martin (IEEE, 2020-07-20)Platelet and fibrin-rich blood clots can respond differently to red blood cell rich clots during ischemic stroke treatment, which includes thrombolysis and mechanical thrombectomy. Currently, there is no accurate way ... -
Does bridging therapy in mechanical thrombectomy increase recanalization rates in ischemic stroke patients affected by acute large vessel occlusion?
Silva Santos, Andreia M.; Rossi, Rosanna; Pandit, Abhay; Fitzgerald, Seán; Mereuta, Oana Madalina; Douglas, Andrew; Thornton, John; Brennan, Paul; Power, Sarah; O’Hare, Alan; Rentzos, Alexandros; Ceder, Erik; Tatlisumak, Turgut; Jood, Katarina; Redfors, Petra; Nordanstig, Annika; Duffy, Sharon; Gilvarry, Michael; McCarthy, Ray; Doyle, Karen M. (SAGE Publications, 2019-05-22)Both intravenous thrombolysis with tissue plasminogen activator (IV-rtPA) and mechanical thrombectomy (MT) increase recanalization rates. We assessed if bridging-therapy (the concomitant use of rtPA and MT) could increase ... -
Does prior administration of rtPA influence acute ischemic stroke clot composition? Findings from the analysis of clots retrieved with mechanical thrombectomy from the RESTORE registry
Rossi, Rosanna; Molina, Sara; Mereuta, Oana Madalina; Douglas, Andrew; Fitzgerald, Seán; Tierney, Ciara; Pandit, Abhay; Brennan, Paul; Power, Sarah; O’Hare, Alan; Gilvarry, Michael; McCarthy, Ray; Magoufis, Georgios; Tsivgoulis, Georgios; Nagy, András; Vadász, Ágnes; Jood, Katarina; Redfors, Petra; Nordanstig, Annika; Ceder, Erik; Dunker, Dennis; Carlqvist, Jeanette; Psychogios, Klearchos; Szikora, István; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen M. (Springer, 2021-08-20)Background and purpose There is still much debate whether bridging-therapy [intravenous thrombolysis (IVT) prior to mechanical thrombectomy (MT)] might be beneficial compared to MT alone. We investigated the effect of IVT ... -
Dose-dependent effects of binge-like methamphetamine dosing on dopamine and neurotrophin levels in rat brain
Moreira da Silva Santos, Andreia; Kelly, John P.; Doyle, Karen M. (Karger Publishers, 2017-10-24)This study investigated the acute effect of a dose range of low-to-moderate binge-like methamphetamine treatments on the regional expression of neurotrophin proteins in the brain and serum 2 h after the last dose, in ... -
Effect of a binge-like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain
Moreira da Silva Santos, Andreia; Kelly, John P.; Dockery, Peter; Doyle, Karen M. (Elsevier, 2018-10-05)Methamphetamine, an amphetamine derivative, is a powerful psychomotor stimulant and commonly used drug of abuse. This study examined the effect of binge-like methamphetamine (MA) dosing (4 x 4 mg/kg, s.c., 2 h apart) on ... -
Effect of N1-Dansylspermine and Ro25,6981 on locomotor activity in naive mice and in the resperpinised mouse model of Parkinson's disease
Devadasan, Carol; Starr, Beryl; Doyle, Karen M. (Lippincott, Williams & Wilkins, 2016-09-01)The effect of N1-dansylspermine, a polyamine analogue and competitive polyamine antagonist, and Ro25,6981, a noncompetitive polyamine antagonist with good affinity and selectivity for the GluN2B subunit, on locomotor ... -
Fatty acid binding protein expression in clots retrieved by mechanical thrombectomy from patients with acute ischaemic stroke
Mereuta, Oana Madalina; Fitzgerald, Seán; Douglas, Andrew; Rossi, Rosanna; Silva Santos, Andreia M.; Pandit, Abhay; Thornton, John; O'Hare, Alan; Power, Sarah; Brennan, Paul; Rentzos, Alexandros; Tatlisumak, Turgut; Gunnarsson, Thorsteinn; Davidson, Maria; Brederlau, Anke; Allardt, Arne; Brinjikji, Waleed; Kallmes, David F.; Doyle, Karen M. (Sage Publications, 2019-05-22)Introduction: Lipid accumulation and inflammation are considered hallmarks of the unstable atherosclerotic plaque. In particular, adipocyte fatty acid binding protein (FABP4) expression within the plaque is associated ... -
Fear-induced suppression of nociceptive behaviour and activation of signal transduction molecules in the rat periaqueductal grey: role of fatty acid amide hydrolase.
Butler, Ryan K.; Ford, Gemma K.; Hogan, Michelle; Roche, Michelle; Doyle, Karen M.; Kelly, John P.; Finn, David P. (Sage, 2011-09-17)The endocannabinoid system regulates nociception and aversion and mediates fear-conditioned analgesia (FCA). We investigated the effects of the fatty acid amide hydrolase (FAAH) inhibitor URB597, which inhibits the catabolism ... -
Histological characterization of white clots retrieved by mechanical thrombectomy from acute ischemic stroke patients
Mereuta, Oana Madalina; Fitzgerald, Seán; Douglas, Andy; Rossi, Rosanna; Silva Santos, Andreia M.; Pandit, Abhay; Thornton, John; Rentzos, Alexandros; Tatlisumak, Turgut; Doyle, Karen M. (SAGE Publications, 2019-01-01)Introduction: Advances in mechanical thrombectomy have created the unique opportunity to study the acute ischemic stroke clot material. However, there is a lack of uniformity in the histopathologic characterization of ... -
Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations
Staessens, S.; Fitzgerald, Seán; Andersson, T.; Clarencon, F.; Denorme, F.; Gounis, M. J.; Hacke, W.; Liebeskind, D. S.; Szikora, I.; van Es, A. C. G. M.; Brinjikji, W.; Doyle, Karen M.; De Meyer, S. F. (SAGE Publications, 2019-11-03)The recent advent of endovascular procedures has created the unique opportunity to collect and analyze thrombi removed from cerebral arteries, instigating a novel subfield in stroke research. Insights into thrombus ... -
Hydroxycinnamic acid amide derivatives of polyamines reverse spermine-induced CNS excitation
Bailey, Desiree; Kirby, Brian P.; Atkinson, Jeffrey; Fixon-Owoo, Solomon; Henman, Martin C.; Shaw, Graham G.; Doyle, Karen M. (Elsevier, 2015-03-28)The aim of this study was to examine the acute effect of a range of novel hydroxycinnamic acid derivatives of spermine on the development of spermine-induced CNS excitation and convulsions in female Laca mice, and to assess ... -
The impact of occlusion location and bridging therapy in patients affected by acute ischemic stroke in determining the total number of passes required to remove the clot and the final revascularization outcome
Rossi, Rosanna; Fitzgerald, Seán; Mereuta, Oana Madalina; Douglas, Andrew; Pandit, Abhay; Szikora, István; Tsivgoulis, Georgios; Psychogios, Klearchos; Murphy, Blathnaid; Brennan, Paul; Power, Sarah; O'Hare, Alan; Thornton, John; Rentzos, Alexandros; Tatlisumak, Turgut; Doyle, Karen M. (WFITN (World Federation of Interventional and Therapeutic Neuroradiology), 2019-10-21)Purpose Our purpose was to assess the impact of occlusion location in patients suffering from Acute Ischemic Stroke (AIS) on the total number of passes (attempts) necessary to retrieve the clot and on final revascularization ... -
Large artery atherosclerotic clots are larger than clots of other stroke etiologies and have poorer recanalization rates
Fitzgerald, Seán; Rossi, Rosanna; Mereuta, Oana Madalina; Molina, Sara; Okolo, Adaobi; Douglas, Andrew; Jabrah, Duaa; Pandit, Abhay; McCarthy, Ray; Gilvarry, Michael; Ceder, Erik; Dehlfors, Niclas; Dunker, Dennis; Nordanstig, Annika; Redfors, Petra; Jood, Katarina; Magoufis, Georgios; Psychogios, Klearchos; Tsivgoulis, Georgios; Alderson, Jack; O’Hare, Alan; Power, Sarah; Brennan, Paul; Nagy, András; Vadász, Ágnes; Brinjikji, Waleed; Kallmes, David; Szikora, Istvan; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen M. (Elsevier, 2020-11-24)Objectives There is a paucity of knowledge in the literature relating to the extent of clot burden and stroke etiology. In this study, we measured the Extracted Clot Area (ECA) retrieved during endovascular treatment (EVT) ... -
Novel human acute ischemic stroke blood clot analogs for in vitro thrombectomy testing
Fitzgerald, Seán; Liu, Yang; Dai, Daying; Mereuta, Oana Madalina; Abbasi, Mehdi; Larco, JL Arturo; Douglas, Andrew; Kallmes, David; Savastano, Luis; Doyle, Karen M.; Brinjikji, Waleed (American Society of Neuroradiology, 2021-04-08)BACKGROUND AND PURPOSE: Previous studies have successfully created blood clot analogs for in vitro endovascular device testing using animal blood of various species. Blood components vary greatly among species; therefore, ... -
Orbit image analysis machine learning software can be used for the histological quantification of acute ischemic stroke blood clots
Fitzgerald, Seán; Wang, Shunli; Dai, Daying; Murphree Jr, Dennis H.; Pandit, Abhay; Douglas, Andrew; Rizvi, Asim; Kadirvel, Ramanathan; Gilvarry, Michael; McCarthy, Ray; Stritt, Manuel; Gounis, Matthew J.; Brinjikji, Waleed; Kallmes, David F.; Doyle, Karen M. (Public Library of Science, 2019-12-05)Our aim was to assess the utility of a novel machine learning software (Orbit Image Analysis) in the histological quantification of acute ischemic stroke (AIS) clots. We analyzed 50 AIS blood clots retrieved using mechanical ... -
Per pass analysis of acute ischemic stroke clots: impact of stroke etiology on extracted-clot-area and histological composition
Fitzgerald, Seán; Rossi, Rosanna; Mereuta, Oana Madalina; Jabrah, Duaa; Okolo, Adaobi; Douglas, Andrew; Molina Gil, Sara; Pandit, Abhay; McCarthy, Ray; Gilvarry, Michael; Dunker, Dennis; Nordanstig, Annika; Ceder, Erik; Redfors, Petra; Jood, Katarina; Dehlfors, Niclas; Magoufis, Georgios; Tsivgoulis, Georgios; Brinjikji, Waleed; Kallmes, David F.; Hare, Alan; Power, Sarah; Brennan, Paul; Alderson, Jack; Nagy, András; Vadász, Ágnes; Psychogios, Klearchos; Szikora, Istvan; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen M. (BMJ Publishing Group, 2020-12-09)Background Initial studies investigating correlations between stroke etiology and clot composition are conflicting and do not account for clot size as determined by area. Radiological studies have shown that cardioembolic ... -
Platelet-rich clots as identified by Martius Scarlet Blue staining are isodense on NCCT
Fitzgerald, Seán; Wang, Shunli; Dai, Daying; Douglas, Andrew; Kadirvel, Ramanathan; Gounis, Matthew J.; Chueh, Juyu; Puri, Ajit S.; Layton, Kennith F.; Thacker, Ike C.; Hanel, Ricardo A.; Sauvageau, Eric; Aghaebrahim, Amin; Almekhlafi, Mohammed A.; Demchuk, Andrew M.; Nogueira, Raul G.; Pereira, Vitor M.; Kvamme, Peter; Kayan, Yasha; Delgado Almandoz, Josser E.; Yoo, Albert J.; Kallmes, David F.; Doyle, Karen M.; Brinjikji, Waleed (BMJ Publishing Group, 2019-04-05)Background Current studies on clot characterization in acute ischemic stroke focus on fibrin and red blood cell composition. Few studies have examined platelet composition in acute ischemic stroke clots. We characterize ...