Browsing School of Medicine by Author "Alkermes Inc."
Now showing items 1-2 of 2
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Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats
Burke, Nikita N.; Li, Yan; Daniel R Deaver, Daniel R.; Deaver, Daniel R.; Finn, David P.; Roche, Michelle; Eyerman, David J.; Sanchez, Connie; Kelly, John P. (SAGE Publications, 2019-09-12)Background: The combination of buprenorphine, a partial mu-opioid receptor agonist and a functional kappa-opioid receptor antagonist, with samidorphan, a functional mu-opioid receptor antagonist, is being developed as an ... -
Prenatal exposure to valproic acid reduces social responses and alters mRNA levels of opioid receptor and pre-pro-peptide in discrete brain regions of adolescent and adult male rats
Hughes, Edel M.; Calcagno, Patricia; Clarke, Morgane; Sanchez, Connie; Smith, Karen; Kelly, John P.; Finn, David P.; Roche, Michelle (Elsevier, 2020-01-21)Altered social behaviours are a hallmark of several psychiatric and developmental disorders. Clinical and preclinical data have demonstrated that prenatal exposure to valproic acid (VPA), an anti-epileptic and mood stabiliser, ...