Browsing School of Medicine by Title
Now showing items 186-205 of 336
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Large artery atherosclerotic clots are larger than clots of other stroke etiologies and have poorer recanalization rates
(Elsevier, 2020-11-24)Objectives There is a paucity of knowledge in the literature relating to the extent of clot burden and stroke etiology. In this study, we measured the Extracted Clot Area (ECA) retrieved during endovascular treatment (EVT) ... -
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
(Nature Publishing Group (Macmillan), 2013-03-27)Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We ... -
Learning from complaints about hospital care
(National University of Ireland Galway, 2022)Complaints are often seen as a negative experience in healthcare, with patients or family members writing about poor experiences of care, or things that went wrong. These things that go wrong may be small issues or ... -
Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord
(Elsevier, 2012-01-08)Background aims. In this study we investigated the effect of neurotrophin-3 (NT-3) and knockdown of NG2, one of the main inhibitory chondroitin sulfate proteoglycans (CSPG), in the glial scar following spinal cord injury ... -
Lentiviral vector‐mediated knockdown of the neuroglycan 2 proteoglycan or expression of neurotrophin‐3 promotes neurite outgrowth in a cell culture model of the glial scar
(Wiley, 2010)Background Following spinal cord injury, a highly inhibitory environment for axonal regeneration develops. One of the main sources of this inhibition is the glial scar that is formed after injury by reactive astrocytes. ... -
Linguistic and Psychometric Validation of the Diabetes-Specific Quality-of-Life Scale in UK English for Adults With Type 1 Diabetes
(American Diabetes Association, 2012-12-18)OBJECTIVE-To develop a linguistically and psychometrically validated U.K. English (U.K.! Ireland) version of the Diabetes-Specific Quality-of-Life Scale (DSQOLS) for adults with type 1 diabetes.RESEARCH DESIGN AND METHODS-We ... -
Lipid lowering therapy, low-density lipoprotein level and risk of intracerebral hemorrhage – a meta-analysis
(Elsevier, 2019-03-14)The association of lipid lowering therapy and intracerebral hemorrhage risk is controversial. We performed a cumulative meta-analysis of lipid lowering trials that reported intracerebral hemorrhage. Statin, fibrate, ... -
Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats
(Elsevier, 2018-12-13)Modulation of the opioid system has re-emerged as a potential therapeutic avenue for treating depression, with efficacy of a fixed-dose combination of buprenorphine (BUP), a partial mu-opioid receptor (MOR) agonist and ... -
A longitudinal qualitative study examining the factors impacting on the ability of persons with T1DM to assimilate the Dose Adjustment For Normal Eating (DAFNE) principles into daily living and how these factors change over time
(BioMed Central, 2011-08-30)The literature reveals that structured education programmes, such as DAFNE, result in many positive outcomes for people with Type 1 diabetes including a decrease in HbA1c levels and reductions in hypoglycaemia. While there ... -
A longitudinal survey of antibiotic-resistant enterobacterales in the Irish environment, 2019–2020
(Elsevier, 2022-03-17)The natural environment represents a complex reservoir of antibiotic-resistant bacteria as a consequence of different wastewater discharges including anthropogenic and agricultural. Therefore, the aim of this study was to ... -
Low-frequency electrical conductivity of trabecular bone: Insights from in silico modeling
(MDPI, 2023-09-23)Background: The electrical conductivity of trabecular bone at 100 kHz has recently been reported as a good predictor of bone volume fraction. However, quantifying its relationship with free water (or physiological solution) ... -
The management of diabetes in adults and children with psychiatric disorders in inpatient settings
(JBDS-IP (Joint British Diabetes Societies for Inpatient Care) and RCPsych (Royal College of Psychiatrists), 2017-05)Nearly every category of ICD-10 Chapter F (mental disorders) is associated with diabetes and with worse outcomes and premature mortality.1 In addition, many people with diabetes suffer from diabetes related distress. The ... -
The maternal and fetal impacts of obesity and gestational diabetes on pregnancy outcome
(2010)Obesity has reached pandemic proportions and is of growing concern worldwide. Adverse health outcomes associated with a raised body mass index present the greatest challenge currently facing clinicians across all ... -
Maternal deprivation is associated with sex-dependent alterations in nociceptive behavior and neuroinflammatory mediators in the rat following peripheral nerve injury
(Elsevier, 2013-10)Early-life stress is associated with an increased risk of developing affective disorders and chronic pain conditions. This study examined the effect of maternal deprivation (MD) on nociceptive responding prior to and ... -
Maternal presence or absence alters nociceptive responding and cortical anandamide levels in juvenile female rats
(Elsevier, 2020-05-30)The influence of parental support on child pain experiences is well recognised. Accordingly, animal studies have revealed both short- and long-term effects of early life stress on nociceptive responding and neural substrates ... -
Maximizing the catheter-to-vessel size optimizes distal flow control resulting in improved revascularization in vitro for aspiration thrombectomy
(BMJ Publishing Group, 2021-03-15)Background Balloon guide catheters (BGCs) achieve proximal flow control during thrombectomy but antegrade intracranial flow often persists via the Circle of Willis. Closely sizing an aspiration catheter to the target vessel ... -
Medical speciality choices: Does personality matter?
(Irish Medical Journal, 2015-08-07)There has been increasing interest in the personalities of doctors. This study examined whether personality differed based upon gender, level of training or medical speciality among 200 physicians and 134 medical students. ... -
Mesenchymal stem cell therapy to promote corneal allograft survival: current status and pathway to clinical translation
(Lippincott, Williams & Wilkins, 2016-12)PURPOSE OF REVIEW: This article reviews the literature on the therapeutic potential of mesenchymal stem cells (MSCs) to prolong corneal allograft survival. RECENT FINDINGS: To date, only small numbers studies have ... -
Mesenchymal stem cell-mediated delivery of the sodium iodide symporter supports radionuclide imaging and treatment of breast cancer
(AlphaMed Press, 2011-05-23)Mesenchymal Stem Cells (MSCs) migrate specifically to tumors in vivo, and coupled with their capacity to bypass immune surveillance, are attractive vehicles for tumor-targeted delivery of therapeutic agents. This study ... -
Mesenchymal Stem Cells (MSCs) and cancer: tumour specific delivery vehicles or therapeutic targets?
(Mary Ann Liebert, 2010-09-30)Mesenchymal stem cells (MSCs) are a subset of nonhematopoietic multipotent cells found primarily within the bone marrow stroma. The ability of MSCs to specifically home to sites of tumors and their metastases, while escaping ...