Browsing School of Medicine by Title

Now showing items 168-187 of 336

    • Influence of stromal–epithelial interactions on breast cancer in vitro and in vivo 

      Potter, Shirley M.; Dwyer, Róisín M.; Hartmann, Marion C.; Khan, Sonja; Boyle, Marie P.; Curran, Catherine E.; Kerin, Michael J. (Springer, 2011-02-23)
      Stromal cell-secreted chemokines including CCL2 have been implicated in the primary tumor microenvironment, as mediators of tumor cell migration, proliferation, and angiogenesis. Expression of CCL2 and its principal receptor ...

    • Inhibition by Anandamide of 6-Hydroxydopamine-Induced Cell Death in PC12 Cells 

      Mnich, Katarzyna; Finn, David P.; Dowd, Eilis; Gorman, Adrienne M. (2010)
      6-hydroxydopamine (6-OHDA) is a selective neurotoxin that is widely used to investigate cell death and protective strategies in models of Parkinson's disease. Here, we investigated the effects of the endogenous cannabinoid, ...

    • Initial psychometric evaluation of a psychological resilience measure for physicians 

      O'Connor, Paul; Lydon, Sinéad; Byrne, Dara (Taylor and Francis, 2019-10-20)
      Measures of Psychological Resilience (PR) for use with physician populations are lacking. The objective of this study is to develop and assess the validity and internal consistency of a survey designed to measure the ...

    • Integrated analyses of microbiome and longitudinal metabolome data reveal microbial-host interactions on sulfur metabolism in Parkinson's disease. 

      Hertel, Johannes; Harms, Amy C.; Heinken, Almut; Baldini, Federico; Thinnes, Cyrille C; Glaab, Enrico; Vasco, Daniel A.; Pietzner, Maik; Stewart, Isobel D.; Wareham, Nicholas J.; Langenberg, Claudia; Trenkwalder, Claudia; Krüger, Rejko; Hankemeier, Thomas; Fleming, Ronan M. T.; Mollenhauer, Brit; Thiele, Ines (Elsevier, 2019-11-12)
      Parkinson's disease (PD) exhibits systemic effects on the human metabolism, with emerging roles for the gut microbiome. Here, we integrate longitudinal metabolome data from 30 drug-naive, de novo PD patients and 30 matched ...

    • Integrated in vitro and in silico modelling delineates the molecular effects of a synbiotic regimen on colorectal cancer-derived cells 

      Greenhalgh, Kacy; Ramiro-Garcia, Javier; Heinken, Almut; Ullmann, Pit; Bintener, Tamara; Pires Pacheco, Maria; Baginska, Joanna; Shah, Pranjul; Frachet, Audrey; Halder, Rashi; Fritz, Joëlle V.; Sauter, Thomas; Thiele, Ines; Haan, Serge; Letellier, Elisabeth; Wilmes, Paul (Cell Press, 2019-04-30)
      By modulating the human gut microbiome, prebiotics and probiotics (combinations of which are called synbiotics) may be used to treat diseases such as colorectal cancer (CRC). Methodological limitations have prevented ...

    • Interns and their smartphones: use for clinical practice 

      O'Connor, Paul; Byrne, Darra; Butt, M.; Lydon, S.; Stewart, Brian; Kerin, M. J. (Medscape, 2014)
      Purpose of the study Smartphone use among healthcare professionals has become widespread and will continue to grow in the coming years.Study design In October 2012, a survey was distributed to 230 interns at two of the ...

    • Intervention to improve the quality of antimicrobial prescribing for urinary tract infection: a cluster randomized trial 

      Vellinga, Akke; Galvin, Sandra; Duane, Sinead; Callan, Aoife; Bennett, Kathleen; Cormican, Martin; Domegan, Christine; Murphy, Andrew W. (Canadian Medical Association, 2015-11-16)
      Background: Overuse of antimicrobial therapy in the community adds to the global spread of antimicrobial resistance, which is jeopardizing the treatment of common infections.Methods: We designed a cluster randomized complex ...

    • Interventions to improve hand hygiene compliance in the ICU: A systematic review 

      Lydon, Sinéad; Power, Michael; McSharry, Jennifer; Byrne, Molly; Madden, Caoimhe; Squires, Janet Elaine; O'Connor, Paul (Lippincott, Williams & Wilkins, 2017-11)
      Objectives: To synthesize the literature describing interventions to improve hand hygiene in ICUs, to evaluate the quality of the extant research, and to outline the type, and efficacy, of interventions described. Data ...

    • An introduction to human factors for healthcare workers 

      O'Connor, Paul; O'Dea, Angela (Health Services Executive, 2021-11-20)
      This document: (1) provides a comprehensive overview of human factors; (2) supports healthcare workers to identify the human factors issues in their workplace; (3) supports the identification of the human factors contributors ...

    • Investigating the management of diabetes in nursing homes using a mixed methods approach 

      Hurley, Lorna; O'Donnell, Máire; Ó Caoimh, Ronan; Dinneen, Seán F. (Elsevier ScienceDirect, 2017-03-21)
      Aims: As populations age there is an increased demand for nursing home (NH) care and a parallel increase in the prevalence of diabetes. Despite this, there is growing evidence that the management of diabetes in NHs is ...

    • Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats 

      Ford, Gemma K.; Moriarty, Orla; Okine, Bright N.; Tully, E.; Mulcahy, A.; Harhen, Brendan; Finn, David P. (Wiley, 2014-11-15)
      BackgroundDistraction is used clinically to relieve and manage pain. It is hypothesized that pain demands attention and that exposure to another attention-demanding stimulus causes withdrawal of attention away from painful ...

    • The Irish DAFNE Study Protocol: A cluster randomised trial of group versus individual follow-up after structured education for Type 1 diabetes 

      Dinneen, Seán F.; O' Hara, Mary Clare; Byrne, Molly; Newell, John; Daly, Lisa (2009)
      Background: Structured education programmes for individuals with Type 1 diabetes have become a recognised means of delivering the knowledge and skills necessary for optimal self-management of the condition. The Dose ...

    • Irish policy-makers' perceptions of barriers and facilitators to hand hygiene compliance 

      Madden, Caoimhe; Lydon, Sinéad; Lambe, Kathryn; O'Connor, Paul (Irish Medical Organisation, 2019-04)
      Introduction Despite its’ role in infection prevention, hand hygiene (HH) compliance rates in healthcare settings remain sub-optimal. Little research has examined policy-makers’ perceptions of contributory barriers and ...

    • Is diabetes self-management education still the Cinderella of diabetes care? 

      Hurley, Lorna; O’Donnell, Máire; O’Hara, Mary Clare; Carey, Marian E.; Willaing, Ingrid; Daly, Heather; Dinneen, Seán F. (Elsevier ScienceDirect, 2017-05-17)
      This paper reflects on the status of diabetes self-management education (DSME) as a branch of diabetology in Europe and discusses some opportunities for better supporting DSME delivery. DSME (also commonly known as Therapeutic ...

    • Isolation of secreted microRNAs (miRNAs) from cell-conditioned media 

      Glynn, Claire L.; Khan, Sonja; Kerin, Michael J.; M. Dwyer, Roisin (2013)
      MicroRNAs (miRNAs) have been found to be stable in the circulation of cancer patients raising their potential as circulating biomarkers of disease. The specific source and role, however, of miRNAs in the circulation is ...

    • Joint association of urinary sodium and potassium excretion with cardiovascular events and mortality: prospective cohort study 

      O’Donnell, Martin; Mente, Andrew; Rangarajan, Sumathy; McQueen, Matthew J.; O’Leary, Neil; Yin, Lu; Liu, Xiaoyun; Swaminathan, Sumathi; Khatib, Rasha; Rosengren, Annika; Ferguson, John; Smyth, Andrew; PURE Investigators (BMJ Publishing Group, 2019-03-13)
      Abstract Objective To evaluate the joint association of sodium and potassium urinary excretion (as surrogate measures of intake) with cardiovascular events and mortality, in the context of current World Health Organization ...

    • Kappa opioid receptor-mediated modulation of social responding in adolescent rats and in rats prenatally exposed to valproic acid 

      Hughes, Edel M.; Thornton, Aoife M.; Kerr, Daniel M.; Smith, Karen; Sanchez, Connie; Kelly, John P.; Finn, David P. (Elsevier, 2020-08-05)
      The kappa opioid receptor (KOP) system modulates social play responding, however a paucity of studies have examined effects on social motivation and cognition in the absence of play. Prenatal exposure to the anti epileptic ...

    • The KRAS-Variant Is Associated with Risk of Developing Double Primary Breast and Ovarian Cancer 

      Kerin, Michael J.; McVeigh, Terri; Dorairaj, Jemima J.; Heneghan, Helen M.; Miller, Nicola (2012)
      Purpose: A germline microRNA binding site-disrupting variant, the KRAS-variant (rs61764370), is associated with an increased risk of developing several cancers. Because this variant is most strongly associated with ovarian ...

    • Large artery atherosclerotic clots are larger than clots of other stroke etiologies and have poorer recanalization rates 

      Fitzgerald, Seán; Rossi, Rosanna; Mereuta, Oana Madalina; Molina, Sara; Okolo, Adaobi; Douglas, Andrew; Jabrah, Duaa; Pandit, Abhay; McCarthy, Ray; Gilvarry, Michael; Ceder, Erik; Dehlfors, Niclas; Dunker, Dennis; Nordanstig, Annika; Redfors, Petra; Jood, Katarina; Magoufis, Georgios; Psychogios, Klearchos; Tsivgoulis, Georgios; Alderson, Jack; O’Hare, Alan; Power, Sarah; Brennan, Paul; Nagy, András; Vadász, Ágnes; Brinjikji, Waleed; Kallmes, David; Szikora, Istvan; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen M. (Elsevier, 2020-11-24)
      Objectives There is a paucity of knowledge in the literature relating to the extent of clot burden and stroke etiology. In this study, we measured the Extracted Clot Area (ECA) retrieved during endovascular treatment (EVT) ...

    • Large-scale genotyping identifies 41 new loci associated with breast cancer risk. 

      Kerin, Michael J.; Miller, Nicola (Nature Publishing Group (Macmillan), 2013-03-27)
      Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We ...