Browsing School of Medicine by Title
Now showing items 140-159 of 293
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Impact of working 48 hours per week on opportunities for training and patient contact: the experience of Irish interns
(Oxford University Press, 2015-09-29)Objective. The European Working Time Regulations (EWTR) have been criticised for its purported negative impact on the training of junior doctors. The aim of this study was to examine the amount of time interns spent ... -
Impaired cued and spatial learning performance and altered cannabinoid CB1 receptor functionality in the substantia nigra in a rat model of diabetic neuropathy
(Elsevier, 2016-01-13)Diabetes, and associated diabetic neuropathic pain, impact negatively on cognitive function. However, the underlying mechanisms remain poorly understood. This study investigated neuropathic pain-related behaviour and ... -
Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimuli
(International Association for the Study of Pain, 2014-01)Pain is both a sensory and an emotional experience, and is subject to modulation by a number of factors including genetic background modulating stress/affect. The Wistar-Kyoto (WKY) rat exhibits a stress-hyper-responsive ... -
Impaired recognition memory and cognitive flexibility in the rat L5-L6 spinal nerve ligation model of neuropathic pain
(De Gruyter, 2016-01-01)Background and aims: Although neuropathic pain is known to negatively affect cognition, the neural mechanisms involved are poorly understood. Chronic pain is associated with changes in synaptic plasticity in the brain which ... -
Improving antimicrobial prescribing: a multinomial model identifying factors associated with first- and second-line prescribing
(Elsevier, 2018-12-13)Background/objectives: Broad-spectrum, second-line antimicrobials may be prescribed when initial first-line options prove ineffective. This study compares prescribing practices and identifies potential influencing factors ... -
In memory of Tom Isaacs: The epitomical mover and shaker
(Wiley, 2018-10-16)[No abstract available] -
Incidental findings on MRI scans of patients presenting with audiovestibular symptoms
(Biomed Central, 2010)Background:The evaluation of patients presenting with audiovestibular symptoms usually includes MRI of the internal auditory meatus, the cerebellopontine angle and the brain. A significant percentage of these scans will ... -
Indistinguishable NDM-producing escherichia coli isolated from recreational waters, sewage, and a clinical specimen in Ireland, 2016 to 2017
(European Centre for Disease Prevention and Control, 2017-04-13)In this study, New Delhi metallo-beta-lactamase (NDM)-producing Enterobacteriaceae were identified in Irish recreational waters and sewage. Indistinguishable NDM-producing Escherichia coli by pulsed-field gel electrophoresis ... -
Inertial sensor technology for elite swimming performance analysis: a systematic review
(MDPI, 2015-12-25)Technical evaluation of swimming performance is an essential factor of elite athletic preparation. Novel methods of analysis, incorporating body worn inertial sensors (i.e., Microelectromechanical systems, or MEMS, ... -
Influence of stromal–epithelial interactions on breast cancer in vitro and in vivo
(Springer, 2011-02-23)Stromal cell-secreted chemokines including CCL2 have been implicated in the primary tumor microenvironment, as mediators of tumor cell migration, proliferation, and angiogenesis. Expression of CCL2 and its principal receptor ... -
Inhibition by Anandamide of 6-Hydroxydopamine-Induced Cell Death in PC12 Cells
(2010)6-hydroxydopamine (6-OHDA) is a selective neurotoxin that is widely used to investigate cell death and protective strategies in models of Parkinson's disease. Here, we investigated the effects of the endogenous cannabinoid, ... -
Initial psychometric evaluation of a psychological resilience measure for physicians
(Taylor and Francis, 2019-10-20)Measures of Psychological Resilience (PR) for use with physician populations are lacking. The objective of this study is to develop and assess the validity and internal consistency of a survey designed to measure the ... -
Integrated analyses of microbiome and longitudinal metabolome data reveal microbial-host interactions on sulfur metabolism in Parkinson's disease.
(Elsevier, 2019-11-12)Parkinson's disease (PD) exhibits systemic effects on the human metabolism, with emerging roles for the gut microbiome. Here, we integrate longitudinal metabolome data from 30 drug-naive, de novo PD patients and 30 matched ... -
Integrated in vitro and in silico modelling delineates the molecular effects of a synbiotic regimen on colorectal cancer-derived cells
(Cell Press, 2019-04-30)By modulating the human gut microbiome, prebiotics and probiotics (combinations of which are called synbiotics) may be used to treat diseases such as colorectal cancer (CRC). Methodological limitations have prevented ... -
Interns and their smartphones: use for clinical practice
(Medscape, 2014)Purpose of the study Smartphone use among healthcare professionals has become widespread and will continue to grow in the coming years.Study design In October 2012, a survey was distributed to 230 interns at two of the ... -
Intervention to improve the quality of antimicrobial prescribing for urinary tract infection: a cluster randomized trial
(Canadian Medical Association, 2015-11-16)Background: Overuse of antimicrobial therapy in the community adds to the global spread of antimicrobial resistance, which is jeopardizing the treatment of common infections.Methods: We designed a cluster randomized complex ... -
Interventions to improve hand hygiene compliance in the ICU: A systematic review
(Lippincott, Williams & Wilkins, 2017-11)Objectives: To synthesize the literature describing interventions to improve hand hygiene in ICUs, to evaluate the quality of the extant research, and to outline the type, and efficacy, of interventions described. Data ... -
Investigating the management of diabetes in nursing homes using a mixed methods approach
(Elsevier ScienceDirect, 2017-03-21)Aims: As populations age there is an increased demand for nursing home (NH) care and a parallel increase in the prevalence of diabetes. Despite this, there is growing evidence that the management of diabetes in NHs is ... -
Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats
(Wiley, 2014-11-15)BackgroundDistraction is used clinically to relieve and manage pain. It is hypothesized that pain demands attention and that exposure to another attention-demanding stimulus causes withdrawal of attention away from painful ... -
The Irish DAFNE Study Protocol: A cluster randomised trial of group versus individual follow-up after structured education for Type 1 diabetes
(2009)Background: Structured education programmes for individuals with Type 1 diabetes have become a recognised means of delivering the knowledge and skills necessary for optimal self-management of the condition. The Dose ...