Browsing School of Medicine by Title
Now showing items 172-191 of 206
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Screening of exosomal microRNAs from colorectal cancer cells
(IOS Press, 2017-01-03)BACKGROUND: Cells release extracellular membrane vesicles including microvesicles known as exosomes. Exosomes contain microRNAs (miRNAs) however the full range within colorectal cancer cell secreted exosomes is unknown.OBJECTIVE: ... -
Screening uptake rates and the clinical and cost effectiveness of screening for gestational diabetes mellitus in primary versus secondary care: study protocol for a randomised controlled trial
(BioMed Central, 2014-01-17)Background: The risks associated with gestational diabetes mellitus (GDM) are well recognized, and there is increasing evidence to support treatment of the condition. However, clear guidance on the ideal approach to screening ... -
Screening uptake rates and the clinical and cost effectiveness of screening for gestational diabetes mellitus in primary versus secondary care: study protocol for a randomised controlled trial
(BioMed Central, 2014-01-17)The risks associated with gestational diabetes mellitus (GDM) are well recognized, and there is increasing evidence to support treatment of the condition. However, clear guidance on the ideal approach to screening for GDM ... -
Shiga toxigenic Escherichia coli incidence is related to small area variation in cattle density in a region in Ireland
(Elsevier, 2018-05-12)Shiga toxigenic Escherichia coli (STEC) are pathogenic E. coli that cause infectious diarrhoea. In some cases infection may be complicated by renal failure and death. The incidence of human infection with STEC in Ireland ... -
Short and long-term effects of gestational diabetes mellitus on the health care cost: cross-sectional comparative study in the ATLANTIC DIP Cohort
(2014-10-21)Previous gestational diabetes (GDM) is associated with a significant lifetime risk of type 2 diabetes. We assessed the performance of HbA1c and fasting plasma glucose (FPG) against 75g oral glucose tolerance testing (OGTT) ... -
Signaling pathways in mouse embryo stem cell self-renewal
(In Tech, 2011)At the pre-implantation blastocyst stage of development, the mammalian embryo is composed of a unique collection of cells of which three major populations predominate. The outermost layer the trophectoderm (TE) gives ... -
Sleep disturbance in adjustment disorder and depressive episode
(MDPI, 2019-03-26)Background: In this paper, we aimed to examine the patterns of sleep disturbance in adjustment disorder (AD) and depressive episode (DE), to examine the variables associated with sleep disturbance in AD and DE and associated ... -
The Sodium Iodide Symporter (NIS) and Potential Regulators in Normal, Benign and Malignant Human Breast Tissue
(2011-01)Introduction: The presence, relevance and regulation of the Sodium Iodide Symporter (NIS) in human mammary tissue remains poorly understood. This study aimed to quantify relative expression of NIS and putative regulators ... -
The spatial distribution of out-of-hospital cardiac arrest and the chain of survival in Ireland: a multi-class urban-rural analysis
(Geographical Society of Ireland, 2016)Abstract: Cardiac arrest occurs when the heart suddenly ceases to pump blood around the body. To optimise survival from out-of-hospital cardiac arrest (OHCA), knowledge of the spatial distribution of OHCA and the availability ... -
The SPHERE Study. Secondary prevention of heart disease in general practice: protocol of a randomised controlled trial of tailored practice and patient care plans with parallel qualitative, economic and policy analyses.
(BioMed Central Ltd., 2005-07-29)Background: The aim of the SPHERE study is to design, implement and evaluate tailored practice and personal care plans to improve the process of care and objective clinical outcomes for patients with established coronary ... -
Strength in Numbers: an international consensus conference to develop a novel approach to care delivery for young adults with type 1 diabetes, the D1 Now Study
(BioMed Central, 2017-12-04)Many young adults with type 1 diabetes struggle with the day-to-day management of their condition. They often find it difficult to find the time to attend their clinic appointments and to meet with their diabetes healthcare ... -
Stress-induced analgesia.
(Butler, R. K. & Finn, D.P. (2009). Stress-induced analgesia. Progress in Neurobiology, 88, 184-202., 2009)For over 30 years, scientists have been investigating the phenomenon of pain suppression upon exposure to unconditioned or conditioned stressful stimuli, commonly known as stress-induced analgesia. These studies have ... -
Stress-induced hyperalgesia
(Elsevier, 2014-07-08)The importance of the modulation of pain by emotion is now widely recognised. In particular, stress and anxiety, depending on their nature, duration and intensity, can exert potent, but complex, modulatory influences ... -
Stromal cell PD-L1iInhibits CD8(+) T-cell antitumor immune responses and promotes colon cancer
(American Association for Cancer Research, 2018-11)Stromal cells of mesenchymal origin reside below the epithelial compartment and provide structural support in the intestine. These intestinal stromal cells interact with both the epithelial cell compartments, as well as ... -
Structural connectivity and rich-club organization in recent onset psychosis
(Elsevier, 2017-05-17)[No abstract available] -
Suicidal behaviours in adjustment disorder and depressive episode
(Elsevier, 2014-12-10)Little is known about suicidal ideation and behaviours in adjustment disorder (AD). In this paper we sought to examine the variables independently associated with suicidal ideation and behaviour in patients diagnosed with ... -
Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate
(2007)Recent physiological, pharmacological and anatomical studies provide evidence that one of the main roles of the endocannabinoid system in the brain is the regulation of ¿-aminobutyric acid (GABA) and glutamate release. ... -
Supraspinal Transient Receptor Potential Subfamily V Member 1 (TRPV1) in pain and psychiatric disorders
(Karger, 2015)The transient receptor potential subfamily V member 1 (TRPV1) belongs to the diverse transient receptor potential (TRP) family of cation channels. It was first characterized in primary afferent fibres as a receptor for ... -
Supraspinal transient receptor potential subfamily V member 1 (TRPV1) in pain and psychiatric disorders
(Karger, 2015)The transient receptor potential subfamily V member 1 (TRPV1) belongs to the diverse transient receptor potential (TRP) family of cation channels. It was first characterized in primary afferent fibres as a receptor for ... -
Surgical checklists: the human factor.
(2013)Surgical checklists has been shown to improve patient safety and teamwork in the operating theatre. However, despite the known benefits of the use of checklists in surgery, in some cases the practical implementation has ...