Browsing School of Medicine by Title
Now showing items 35-54 of 336
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Barriers and facilitators related to the implementation of a physiological track and trigger system: A systematic review of the qualitative evidence
(Oxford University Press (OUP), 2017-11-21)Purpose To identify the barriers to, and facilitators of, the implementation of physiological track and trigger systems (PTTSs), perceived by healthcare workers, through a systematic review of the extant qualitative ... -
Behaviour change techniques targeting both diet and physical activity in type 2 diabetes: A systematic review and meta-analysis
(BioMed Central, 2017-02-08)Background: Changing diet and physical activity behaviour is one of the cornerstones of type 2 diabetes treatment, but changing behaviour is challenging. The objective of this study was to identify behaviour change techniques ... -
Behavioural, neurochemical and neuroendocrine effects of the endogenous beta-carboline harmane in fear-conditioned rats
(2012)The putative endogenous imidazoline binding site ligand harmane enhances neuronal activation in response to psychological stress and alters behaviour in animal models of anxiety and antidepressant efficacy. However, the ... -
Bipolar disorder and gender are associated with frontolimbic and basal ganglia dysconnectivity: A study of topological variance using network analysis
(Mary Ann Liebert, 2019-12-16)Well-established structural abnormalities, mostly involving the limbic system, have been associated with disorders of emotion regulation. Understanding the arrangement and connections of these regions with other functionally ... -
Brain CB2 receptors: Implication for Neuropsychiatric disorders
(2010)Although previously thought of as the peripheral cannabinoid receptor, it is now accepted that the CB2 receptor is expressed in the central nervous system on microglia, astrocytes and subpopulations of neurons. Expression ... -
Brain repair for Parkinson's disease: is the answer in the matrix?
(Medknow Publications, 2018-07-13)Two hundred years after James Parkinson first described the cardinal motor symptoms of the disorder that would later bear his name, there is still an irrefutable need for a therapy that targets the underlying pathophysiology ... -
Breast cancer research output, 1945-2008: a bibliometric and density-equalizing analysis
(BioMed Central, 2010-12)Introduction: Breast cancer is the most common form of cancer among women, with an estimated 194,280 new cases diagnosed in the United States in 2009 alone. The primary aim of this work was to provide an in-depth evaluation ... -
Cannabinoids and pain: sites and mechanisms of action
(Elsevier, 2017-06-20)The endocannabinoid system, consisting of the cannabinoid(1) receptor (CB1R) and cannabinoid(2) receptor (CB2R), endogenous cannabinoid ligands (endocannabinoids), and metabolizing enzymes, is present throughout the pain ... -
Cardioneuroablation using epicardial pulsed field ablation for the treatment of atrial fibrillation
(MDPI, 2023-05-29)Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting millions of people worldwide. The cardiac autonomic nervous system (ANS) is widely recognized as playing a key role in both the initiation and ... -
Career choices of today's medical students: where does surgery rank?
(Springer, 2013-11-15)The national junior doctor recruitment crisis prompts an appraisal of medical student attitudes to different career pathways. The purpose of this study was to perform a national review of surgical career intentions of Irish ... -
Cell viability in three ex vivo rat models of spinal cord injury
(Wiley, 2018-11-11)Spinal cord injury (SCI) is a devastating disorder that has a poor prognosis of recovery. Animal models of SCI are useful to understand the pathophysiology of SCI and the potential use of therapeutic strategies for human ... -
Central CB2 receptors in inflammation-driven neurodegeneration: dysregulation and therapeutic potential
(Medknow Publications, 2016-10-19)In recent times there has been an intensification of interest in the pathological role of neuroinflammation in neurodegenerative disease. Neuroprotective strategies to slow, halt or reverse neurodegeneration have not proven ... -
Changing antibiotic prescribing in General Practice – The results of the SIMPle process evaluation
(Sciedu Press, 2017)Objective: The Supporting the Improvement and Management of Prescribing for Urinary Tract Infections (SIMPle) study, a cluster randomized trial, sought to improve the quality of antibiotic prescribing for Urinary Tract ... -
Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia
(Elsevier, 2016-12-01)The stress-hyperresponsive Wistar-Kyoto (WRY) rat strain exhibits a hyperalgesic phenotype and is a useful genetic model for studying stress-pain interactions. Peroxisome proliferator-activated receptor (PPAR) signalling ... -
Characterization of the affective component of acute postoperative pain associated with a novel rat model of inguinal hernia repair pain
(Wiley, 2015-12-10)Aims: Acute postoperative pain remains a significant healthcare issue. Historically, the assessment of postoperative pain in rodents has relied on evoked withdrawal or reflexive measures. Using a recently developed, ... -
Chlamydia trachomatis infection and sexual behaviour among female students attending higher education in the Republic of Ireland
(2009)Background There are no prevalence data on Chlamydia trachomatis relating to female students attending higher education available for the Republic of Ireland. This information is required to guide on the necessity for ... -
Chondrocytes derived from mesenchymal stromal cells and induced pluripotent cells of patients with familial osteochondritis dissecans exhibit an endoplasmic reticulum stress response and defective matrix assembly
(Wiley, 2016-07-07)Familial osteochondritis dissecans (FOCD) is an inherited skeletal defect characterized by the development of large cartilage lesions in multiple joints, short stature, and early onset of severe osteoarthritis. It is ... -
Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype
(Elsevier, 2015-02)Chronic pain and depression share a complex, reciprocal relationship. Furthermore, in addition to treating depression, antidepressants such as amitriptyline are a first-line treatment for chronic pain conditions, indicating ... -
Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats
(SAGE Publications, 2019-09-12)Background: The combination of buprenorphine, a partial mu-opioid receptor agonist and a functional kappa-opioid receptor antagonist, with samidorphan, a functional mu-opioid receptor antagonist, is being developed as an ... -
Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomised rat
(2007)The olfactory bulbectomized (OB) rat is a well characterized animal model that exhibits a number of behavioural and neurochemical changes that have relevance to clinical depression. Hyperactivity in the open field is the ...