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Mesenchymal stem cell therapy to promote corneal allograft survival: current status and pathway to clinical translation
(Lippincott, Williams & Wilkins, 2016-12)
PURPOSE OF REVIEW: This article reviews the literature on the therapeutic potential of mesenchymal stem cells (MSCs) to prolong corneal allograft survival.
RECENT FINDINGS: To date, only small numbers studies have ...
Third-party allogeneic mesenchymal stromal cells prevent rejection in a pre-sensitized high-risk model of corneal transplantation
(Frontiers Media, 2018-11-20)
High-risk cornea transplant recipients represent a patient population with significant un-met medical need for more effective therapies to prevent immunological graft rejection due to heightened anti-donor immune response. ...
Subconjunctival administration of low-dose murine allogeneic mesenchymal stromal cells promotes corneal allograft survival in mice
(BMC, 2021-04-06)
Systemic administration of mesenchymal stromal cells (MSCs) has been efficacious in many inflammatory disease settings; however, little data are available on the potential immunomodulatory effects following local MSC ...
Immunomodulatory function of licensed human bone marrow mesenchymal stromal cell-derived apoptotic bodies
(Elsevier, 2023-10-23)
Background
Mesenchymal stromal cells (MSCs) show great potential for immunomodulatory and anti-inflammatory treatments. Clinical trials have been performed for the treatment of Type 1 diabetes, graft-versus-host disease ...