College of Medicine, Nursing and Health Sciences: Recent submissions
Now showing items 1-20 of 611
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Suicidal behaviours in adjustment disorder and depressive episode
(Elsevier, 2014-12-10)Little is known about suicidal ideation and behaviours in adjustment disorder (AD). In this paper we sought to examine the variables independently associated with suicidal ideation and behaviour in patients diagnosed with ... -
Critical care nurses experiences of providing care for adults in a highly technological environment: A qualitative evidence synthesis
(Wiley, 2019-08-20)Abstract Aims To synthesise the available body of qualitative evidence relating to nurses' perceptions and experiences of care provision in adult critical care environments. Methods The study adhered to ENTREQ ... -
The management of diabetes in adults and children with psychiatric disorders in inpatient settings
(JBDS-IP (Joint British Diabetes Societies for Inpatient Care) and RCPsych (Royal College of Psychiatrists), 2017-05)Nearly every category of ICD-10 Chapter F (mental disorders) is associated with diabetes and with worse outcomes and premature mortality.1 In addition, many people with diabetes suffer from diabetes related distress. The ... -
Communication skills of medical students during the OSCE: Gender-specific differences in a longitudinal trend study
(BMC, 2017-05-02)Background: Communication skills are essential in a patient-centred health service and therefore in medical teaching. Although significant differences in communication behaviour of male and female students are known, gender ... -
The effect of antidepressant medications in the management of heart failure on outcomes: mortality, cardiovascular function and depression - a systematic review
(Taylor & Francis, 2017-11-26)Depression is associated with increased morbidity, mortality and hospital readmission in patients with heart failure (HF). This systematic review aimed to compile studies examining whether the use of antidepressants could ... -
The clinical characteristics and correlates of lithium toxicity in a tertiary referral centre
(Springer Verlag, 2019-01-10)Introduction Lithium is a medication indicated for the treatment of bipolar disorder and treatment-resistant depression, with a narrow therapeutic index. Overdose, either acute or chronic can result in neurological symptoms, ... -
A pilot study of an integrated mental health, social and medical model for diabetes care in an inner-city setting: Three Dimensions for Diabetes (3DFD).
(Wiley, 2019-02-01)We examined the effectiveness of a service innovation, Three Dimensions for Diabetes (3DFD), that consisted of a referral to an integrated mental health, social care and diabetes treatment model, compared with usual care ... -
Sleep disturbance in adjustment disorder and depressive episode
(MDPI, 2019-03-26)Background: In this paper, we aimed to examine the patterns of sleep disturbance in adjustment disorder (AD) and depressive episode (DE), to examine the variables associated with sleep disturbance in AD and DE and associated ... -
The role of religion in buffering the impact of stressful life events on depressive symptoms in patients with depressive episodes or adjustment disorder.
(MDPI, 2019-04-08)Most studies into the role of religiousness in relation to depression severity have mainly found an inverse relationship between greater religiousness and lower levels of depressive symptoms. There is reason to assume that ... -
Referral of patients to plastic surgeons following self-harm: Opportunities for suicide prevention
(Elsevier, 2018-11-13)Self-harm is a common source of referral to plastic and hand surgery services. Appropriate management of these patients is complex and includes the need for close liaison with mental health services. Self-harm is the single ... -
Prevalence and co-variates of burnout in consultant hospital doctors: burnout in consultants in Ireland Study (BICDIS)
(Springer Verlag, 2018-08-20)Objectives Burnout is prevalent among doctors and affects the quality of patient care. Little research on burnout in consultant-level doctors has been done. The objective of this study was to measure burnout in the hospital ... -
Adjustment disorder and suicidal behaviours presenting in the general medical setting: A systematic review
(MDPI, 2019-08-18)Background: Adjustment disorder (AD) is a condition commonly encountered by clinicians in emergency departments and liaison psychiatry settings and has been frequently reported among patients presenting with suicidal ... -
Adenovirus-mediated and targeted expression of the sodium-iodide symporter permits in vivo radioiodide imaging and therapy of pancreatic tumors
(Mary Ann Liebert, 2006-06-15)Pancreatic cancer is the fourth leading cause of cancer death in the United States. It is highly aggressive with no uniformly effective chemotherapy available for metastatic disease. The sodium–iodide symporter (NIS) is a ... -
Mesenchymal stem cell-mediated delivery of the sodium iodide symporter supports radionuclide imaging and treatment of breast cancer
(AlphaMed Press, 2011-05-23)Mesenchymal Stem Cells (MSCs) migrate specifically to tumors in vivo, and coupled with their capacity to bypass immune surveillance, are attractive vehicles for tumor-targeted delivery of therapeutic agents. This study ... -
Relationship between CCL5 and transforming growth factor-β1 (TGFβ1) in breast cancer
(Elsevier, 2011-06-12)Purpose Investigate circulating CCL5 in breast cancer patients and healthy controls, along with gene expression levels in corresponding tumour tissue and isolated primary stromal cells. Hormonal control of CCL5, and a ... -
Influence of stromal–epithelial interactions on breast cancer in vitro and in vivo
(Springer, 2011-02-23)Stromal cell-secreted chemokines including CCL2 have been implicated in the primary tumor microenvironment, as mediators of tumor cell migration, proliferation, and angiogenesis. Expression of CCL2 and its principal receptor ... -
Screening of exosomal microRNAs from colorectal cancer cells
(IOS Press, 2017-01-03)BACKGROUND: Cells release extracellular membrane vesicles including microvesicles known as exosomes. Exosomes contain microRNAs (miRNAs) however the full range within colorectal cancer cell secreted exosomes is unknown.OBJECTIVE: ... -
Systemic chemokine levels in breast cancer patients and their relationship with circulating menstrual hormones
(Springer, 2008-06-04)Introduction The chemokines Stromal Cell-Derived Factor-1 alpha (SDF-1 alpha/CXCL12) and Monocyte Chemotactic Protein-1 (MCP-1/CCL2) have been implicated in breast cancer progression. We recently reported elevated systemic ... -
Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT)
(Springer, 2010-01-20)Bone marrow-derived mesenchymal stem cells (MSCs) are known to specifically migrate to and engraft at tumour sites. Understanding interactions between cancer cells and MSCs has become fundamental to determining whether ... -
Mesenchymal Stem Cells (MSCs) and cancer: tumour specific delivery vehicles or therapeutic targets?
(Mary Ann Liebert, 2010-09-30)Mesenchymal stem cells (MSCs) are a subset of nonhematopoietic multipotent cells found primarily within the bone marrow stroma. The ability of MSCs to specifically home to sites of tumors and their metastases, while escaping ...