College of Medicine, Nursing and Health Sciences: Recent submissions
Now showing items 1-20 of 663
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A phenomenological study of occupational participation for people who identify as transgender
(Healio, 2020-03-12)Abstract INTRODUCTION: The challenges that transgender people face, which are caused by a multitude of factors, have been well documented. However, changes in occupational participation are less well known. This research ... -
Perceived social benefits versus perceived harms of smoking among Indonesian boys aged 12–16 years: A secondary analysis of Global Youth Tobacco Survey 2014
(EU European Publishing, 2020-02-03)Introduction: Smoking among boys has not been prioritised as a gender issue despite its high prevalence worldwide. In Indonesia, steep increases in prevalence have been observed in adolescent boys. This study explored how ... -
Evaluating the feasibility and preliminary efficacy of a Cognitive Occupation-Based programme for people with Multiple Sclerosis (COB-MS): protocol for a feasibility cluster-randomised controlled trial
(BMC (part of Springer Nature), 2020-03-17)Background Cognitive difficulties experienced by people with multiple sclerosis (MS) impact their quality of life and daily functioning, from childcare and work, to social and self-care activities. Despite the high ... -
An examination of the effects of a patient-designed-and-informed participant information sheet in comparison with a standard, researcher-designed information sheet on recruitment, retention and understanding: Protocol for a study-within-a-trial
(F1000Research, 2020-01-24)Background: This protocol describes a double-blind, randomised non-inferiority study-within-a-trial (SWAT), comparing the effects of a patient-designed-and-informed participant information sheet with a standard, ... -
Influenza vaccine uptake and attitudes of healthcare workers in Ireland
(Oxford University Press (OUP), 2019-11-05)Influenza vaccination uptake by Irish healthcare workers remains sub-optimal despite local initiatives to increase it. To investigate hospital workers' attitudes to influenza vaccination and how this influenced their ... -
Hydroxycinnamic acid amide derivatives of polyamines reverse spermine-induced CNS excitation
(Elsevier, 2015-03-28)The aim of this study was to examine the acute effect of a range of novel hydroxycinnamic acid derivatives of spermine on the development of spermine-induced CNS excitation and convulsions in female Laca mice, and to assess ... -
Distinctive effects of eicosapentaenoic and docosahexaenoic acids in regulating neural stem cell fate are mediated via endocannabinoid signalling pathways
(Elsevier, 2016-04-01)Emerging evidence suggests a complex interplay between the endocannabinoid system, omega-3 fatty acids and the immune system in the promotion of brain self-repair. However, it is unknown if all omega 3 fatty acids elicit ... -
The educational preparation for nurses providing complex care to children in the community setting
(National University of Ireland Galway, 2019-11-21)The number of children with complex care needs has increased over the past decade. This is due to advances in medical science, pharmacology, technology and care (Brenner et al., 2015 Cocket, 2012 & Cohen et al., 2011). ... -
Histological characterization of white clots retrieved by mechanical thrombectomy from acute ischemic stroke patients
(SAGE Publications, 2019-01-01)Introduction: Advances in mechanical thrombectomy have created the unique opportunity to study the acute ischemic stroke clot material. However, there is a lack of uniformity in the histopathologic characterization of ... -
Orbit image analysis machine learning software can be used for the histological quantification of acute ischemic stroke blood clots
(Public Library of Science, 2019-12-05)Our aim was to assess the utility of a novel machine learning software (Orbit Image Analysis) in the histological quantification of acute ischemic stroke (AIS) clots. We analyzed 50 AIS blood clots retrieved using mechanical ... -
Polyamines in the brain: distribution, biological interactions, and their potential therapeutic role in brain ischaemia
(Bentham Science Publishers, 2007)The endogenous polyamines (spermine, spermidine, and putrescine) are present at relatively high concentrations in the mammalian brain and play crucial roles in a variety of aspects of cell functioning. Stroke is the third ... -
The development of translational biomarkers as a tool for improving the understanding, diagnosis and treatment of chronic neuropathic pain
(Springer, 2017-03-30)Chronic neuropathic pain (CNP) is one of the most significant unmet clinical needs in modern medicine. Alongside the lack of effective treatments, there is a great deficit in the availability of objective diagnostic methods ... -
Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations
(SAGE Publications, 2019-11-03)The recent advent of endovascular procedures has created the unique opportunity to collect and analyze thrombi removed from cerebral arteries, instigating a novel subfield in stroke research. Insights into thrombus ... -
Dose-dependent effects of binge-like methamphetamine dosing on dopamine and neurotrophin levels in rat brain
(Karger Publishers, 2017-10-24)This study investigated the acute effect of a dose range of low-to-moderate binge-like methamphetamine treatments on the regional expression of neurotrophin proteins in the brain and serum 2 h after the last dose, in ... -
Effect of a binge-like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain
(Elsevier, 2018-10-05)Methamphetamine, an amphetamine derivative, is a powerful psychomotor stimulant and commonly used drug of abuse. This study examined the effect of binge-like methamphetamine (MA) dosing (4 x 4 mg/kg, s.c., 2 h apart) on ... -
Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure
(Elsevier, 2019-11-03)Methamphetamine (MA), a synthetic derivate of amphetamine, has become a major drug of abuse worldwide. This study investigated the effect of binge-like MA dosing (4 x 4 mg/kg, s.c., 2 h (h) apart) at a range of different ... -
Effect of N1-Dansylspermine and Ro25,6981 on locomotor activity in naive mice and in the resperpinised mouse model of Parkinson's disease
(Lippincott, Williams & Wilkins, 2016-09-01)The effect of N1-dansylspermine, a polyamine analogue and competitive polyamine antagonist, and Ro25,6981, a noncompetitive polyamine antagonist with good affinity and selectivity for the GluN2B subunit, on locomotor ... -
Animal models of focal cerebral ischaemia and haemorrhage transformation: considerations in experimental stroke study design
(Bentham Science Publishers, 2017)Background: Ischaemic stroke is often complicated with haemorrhage within the infarct zone or in a remote location especially when treated with intravenous thrombolysis and/or thrombectomy. While these early recanalisation ... -
Fatty acid binding protein expression in clots retrieved by mechanical thrombectomy from patients with acute ischaemic stroke
(Sage Publications, 2019-05-22)Introduction: Lipid accumulation and inflammation are considered hallmarks of the unstable atherosclerotic plaque. In particular, adipocyte fatty acid binding protein (FABP4) expression within the plaque is associated ... -
Alterations in the central opioid system following acute swim stress and olfactory bulbectomy in the rat
(Elsevier, 2019-12-13)Introduction: Stress is a major component of many animal models of depression, induced acutely as in the forced swim test, or more long-term in the olfactory bulbectomy (OB) and chronic mild stress models [1]. The central ...