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The prefrontal cortical endocannabinoid system modulates fear–pain interactions in a subregion‐specific manner
(Wiley, 2018-05-30)
Background and Purpose
The emotional processing and coordination of top‐down responses to noxious and conditioned aversive stimuli involves the medial prefrontal cortex (mPFC). Evidence suggests that subregions of the ...
Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats
(Elsevier, 2018-12-13)
Modulation of the opioid system has re-emerged as a potential therapeutic avenue for treating depression, with efficacy of a fixed-dose combination of buprenorphine (BUP), a partial mu-opioid receptor (MOR) agonist and ...
FAAH inhibition attenuates TLR3-mediated hyperthermia, nociceptive- and anxiety-like behaviour in female rats
(Elsevier, 2018-06-25)
Aberrant activation of toll-like receptor (TLR)s results in persistent and prolonged neuroinflammation and has been implicated in the pathogenesis and exacerbation of psychiatric and neurodegenerative disorders. TLR3 ...