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The prefrontal cortical endocannabinoid system modulates fear–pain interactions in a subregion‐specific manner
Background and Purpose The emotional processing and coordination of top‐down responses to noxious and conditioned aversive stimuli involves the medial prefrontal cortex (mPFC). Evidence suggests that subregions of the ...
Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats
Modulation of the opioid system has re-emerged as a potential therapeutic avenue for treating depression, with efficacy of a fixed-dose combination of buprenorphine (BUP), a partial mu-opioid receptor (MOR) agonist and ...