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The effect of antidepressant medications in the management of heart failure on outcomes: mortality, cardiovascular function and depression - a systematic review
(Taylor & Francis, 2017-11-26)
Depression is associated with increased morbidity, mortality and hospital readmission in patients with heart failure (HF). This systematic review aimed to compile studies examining whether the use of antidepressants could ...
Suicidal behaviours in adjustment disorder and depressive episode
(Elsevier, 2014-12-10)
Little is known about suicidal ideation and behaviours in adjustment disorder (AD). In this paper we sought to examine the variables independently associated with suicidal ideation and behaviour in patients diagnosed with ...
Employing mesenchymal stem cells to support tumor-targeted delivery of extracellular vesicle (EV)-encapsulated microRNA-379
(Springer Nature, 2018-01-25)
Adult Mesenchymal Stem Cells (MSCs) have a well-established tumor-homing capacity, highlighting potential as tumor-targeted delivery vehicles. MSCs secrete extracellular vesicle (EV)-encapsulated microRNAs, which play a ...
Early intervention and management of adrenal insufficiency in children
(RCN Publishing, 2012-09-11)
Sinéad Moloney and Maura Dowling outline how to treat this hormonal disorder and suggest ways to improve parental and carer education
The endocrine disorder adrenal insufficiency includes inadequate production of the ...
Myeloma: making sense of a complex blood cancer
(Mark Allen Healthcare, 2010)
Myeloma is a challenging blood cancer characterized by bone destruction, hypercalcaemia, renal insufficiency and anaemia. Although myeloma remains incurable, recent advancements in treatments have resulted in significant ...
Patients’ lived experience of myeloma
(RCN Publishing, 2011-03-16)
Aim
To explore patients’ lived experience of being diagnosed with myeloma.
Method
A hermeneutic phenomenological approach was adopted to analyse data from interviews with 11 patients diagnosed with myeloma.
Findi ...
Acute ischemic stroke secondary to cardiac embolus of a ‘foreign body’ material after a redo sternotomy for mitral valve replacement: A case report
(SAGE Publications, 2018-11-14)
Cardiac surgery has been shown to be associated with increased risk of acute ischemic stroke. This report presents a case of a successful mechanical embolectomy procedure to treat a patient for an acute ischemic stroke, ...
The role of the brain's endocannabinoid system in pain and its modulation by stress
(Elsevier, 2015-11-06)
Stress has a complex, bidirectional modulatory influence on pain. Stress may either reduce (stress-induced analgesia) or exacerbate (stress-induced hyperalgesia) pain depending on the nature, duration, and intensity of the ...
Building capacity in workplace health promotion: the case of the Healthy Together e-learning project
(2010-03-26)
The current global economic crisis poses major challenges for workplace health promotion (WHP). Activities that are not perceived to obviously and directly contribute to profits could be sacrificed. This paper argues that ...
Impaired recognition memory and cognitive flexibility in the rat L5-L6 spinal nerve ligation model of neuropathic pain
(De Gruyter, 2016-01-01)
Background and aims: Although neuropathic pain is known to negatively affect cognition, the neural mechanisms involved are poorly understood. Chronic pain is associated with changes in synaptic plasticity in the brain which ...