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Neuroinflammatory mechanisms linking pain and depression
Depression and chronic pain have been estimated to co-occur in up to 80% of patients suffering from these disorders, with this co-morbidity being more disabling and more expensive to both patients and society than either ...
Supraspinal transient receptor potential subfamily V member 1 (TRPV1) in pain and psychiatric disorders
The transient receptor potential subfamily V member 1 (TRPV1) belongs to the diverse transient receptor potential (TRP) family of cation channels. It was first characterized in primary afferent fibres as a receptor for ...
The role of the brain's endocannabinoid system in pain and its modulation by stress
Stress has a complex, bidirectional modulatory influence on pain. Stress may either reduce (stress-induced analgesia) or exacerbate (stress-induced hyperalgesia) pain depending on the nature, duration, and intensity of the ...