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The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nocicpetive tone
(Wiley, 2011)
Background and purpose: Endocannabinoids in the midbrain periaqueductal grey (PAG) are involved in modulating nociception and unconditioned stress-induced analgesia, however, their role in fear-conditioned analgesia (FCA) ...
Fear-induced suppression of nociceptive behaviour and activation of signal transduction molecules in the rat periaqueductal grey: role of fatty acid amide hydrolase.
(Sage, 2011-09-17)
The endocannabinoid system regulates nociception and aversion and mediates fear-conditioned analgesia (FCA). We investigated the effects of the fatty acid amide hydrolase (FAAH) inhibitor URB597, which inhibits the catabolism ...
Neuroinflammatory mechanisms linking pain and depression
(Karger, 2015)
Depression and chronic pain have been estimated to co-occur in up to 80% of patients suffering from these disorders, with this co-morbidity being more disabling and more expensive to both patients and society than either ...
Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala
(Wiley, 2013-08-29)
The association between chronic pain and depression is widely recognized, the comorbidity of which leads to a heavier disease burden, increased disability and poor treatment response. This study examined nociceptive ...
Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate
(2007)
Recent physiological, pharmacological and anatomical studies provide evidence that one of the main roles of the endocannabinoid system in the brain is the regulation of ¿-aminobutyric acid (GABA) and glutamate release. ...
Modulation of Conditioned Fear, Fear-Conditioned Analgesia, and Brain Regional C-Fos Expression Following Administration of Muscimol into the Rat Basolateral Amygdala
(Elsevier, 2011-04)
Evidence suggests that gamma-aminobutyric acid (GABA) signalling in the basolateral amygdala (BLA) is involved in pain, fear, and fear-conditioned analgesia (FCA). In this study, we investigated the effects of intra-BLA ...
Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains
(Elsevier, 2015-05-16)
Repeated exposure to a homotypic stressor such as forced swimming enhances nociceptive responding in rats. However, the influence of genetic background on this stress-induced hyperalgesia is poorly understood. The aim of ...
Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey
(Elsevier, 2016-08-09)
Negative affective state has a significant impact on pain, and genetic background is an important moderating influence on this interaction. The Wistar-Kyoto (WKY) inbred rat strain exhibits a stress-hyperresponsive, ...
Stress-induced hyperalgesia
(Elsevier, 2014-07-08)
The importance of the modulation of pain by emotion is now widely recognised. In particular, stress and anxiety, depending on their nature, duration and intensity, can exert potent, but complex, modulatory influences ...
Supraspinal transient receptor potential subfamily V member 1 (TRPV1) in pain and psychiatric disorders
(Karger, 2015)
The transient receptor potential subfamily V member 1 (TRPV1) belongs to the diverse transient receptor potential (TRP) family of cation channels. It was first characterized in primary afferent fibres as a receptor for ...