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Pharmacological inhibition of monoacylglycerol lipase attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action
(2013)
Background and purpose: This study determined the effect of JZL184, a selective inhibitor of monoacylglycerol lipase (MAGL), the enzyme which preferentially catabolises the endocannabinoid 2-arachidonoyl glycerol (2-AG), ...
Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the rat hypothalamus following an immunological stressor
(2012)
The endocannabinoid system is an important regulator of the nervous, neuroendocrine and
immune systems, thus representing a novel therapeutic target for stress-related
neuroinflammatory and psychiatric disorders. However, ...
Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor
(Elsevier, 2011-09)
The endocannabinoid system is an important regulator of the nervous, neuroendocrine, and immune systems, thus representing a novel therapeutic target for stress-related neuroinflammatory and psychiatric disorders. However, ...
For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders
(Elsevier, 2015-03-17)
Toll-like receptors (TLRs) mediate the innate immune response to pathogens and are critical in the host defence, homeostasis and response to injury. However, uncontrolled and aberrant TLR activation can elicit potent effects ...
Endocannabinoid modulation of inflammatory hyperalgesia in the IFN-α mouse model of depression
(Elsevier, 2019-09-07)
Depression is a well-recognised effect of long-term treatment with interferon-alpha (IFN-alpha), a widely used treatment for chronic viral hepatitis and malignancy. In addition to the emotional disturbances, high incidences ...