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Differential role of anterior cingulate cortical glutamatergic neurons in pain-related aversion learning and nociceptive behaviors in male and female rats

Jarrin, Sarah; Pandit, Abhay; Roche, Michelle; Finn, David P. (Frontiers Media, 2020-08-11)

Pain is comprised of both sensory and affective components. The anterior cingulate cortex (ACC) is a key brain region involved in the emotional processing of pain. Specifically, glutamatergic transmission within the ACC ...

Antinociceptive effects of the GPR55 Antagonist CID16020046 injected into the rat anterior cingulate cortex

Okine, Bright N.; Mc Laughlin, Gemma; Gaspar, Jessica C.; Harhen, Brendan; Roche, Michelle; Finn, David P. (Elsevier, 2020-07-13)

The G-protein coupled receptor, GPR55, modulates nociceptive processing. Given the expression of GPR55 in the anterior cingulate cortex (ACC), a key brain region involved in the cognitive and affective dimensions of pain, ...