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Hydroxycinnamic acid amide derivatives of polyamines reverse spermine-induced CNS excitation

Bailey, Desiree; Kirby, Brian P.; Atkinson, Jeffrey; Fixon-Owoo, Solomon; Henman, Martin C.; Shaw, Graham G.; Doyle, Karen M. (Elsevier, 2015-03-28)

The aim of this study was to examine the acute effect of a range of novel hydroxycinnamic acid derivatives of spermine on the development of spermine-induced CNS excitation and convulsions in female Laca mice, and to assess ...

Employing mesenchymal stem cells to support tumor-targeted delivery of extracellular vesicle (EV)-encapsulated microRNA-379

O’Brien, K. P.; Khan, S.; Gilligan, K. E.; Zafar, H.; Lalor, P.; Glynn, C.; O’Flatharta, C.; Ingoldsby, H.; Dockery, P.; De Bhulbh, A.; Schweber, J. R.; St John, K.; Leahy, M.; Murphy, J. M.; Gallagher, W. M.; O’Brien, T.; Kerin, Michael J.; Dwyer, Róisín M. (Springer Nature, 2018-01-25)

Adult Mesenchymal Stem Cells (MSCs) have a well-established tumor-homing capacity, highlighting potential as tumor-targeted delivery vehicles. MSCs secrete extracellular vesicle (EV)-encapsulated microRNAs, which play a ...