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Development and characterization of a novel, anatomically relevant rat model of acute postoperative pain
(Elsevier, 2015-01-30)
Acute postoperative pain remains a significant health care issue. Development of anatomically relevant animal models of postoperative pain, with improved predictive validity, would advance understanding of postoperative ...
Parental presence at anaesthesia induction: A systematic review
(Wiley, 2016-06-07)
This systematic review assessed the effectiveness of parental presence for children undergoing surgical or diagnostic procedures under general anaesthesia (such as bronchoscopy, laryngoscopy and laparoscopy). Randomized ...
Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats
(SAGE Publications, 2019-09-12)
Background: The combination of buprenorphine, a partial mu-opioid receptor agonist and a functional kappa-opioid receptor antagonist, with samidorphan, a functional mu-opioid receptor antagonist, is being developed as an ...
Kappa opioid receptor-mediated modulation of social responding in adolescent rats and in rats prenatally exposed to valproic acid
(Elsevier, 2020-08-05)
The kappa opioid receptor (KOP) system modulates social play responding, however a paucity of studies have examined effects on social motivation and cognition in the absence of play. Prenatal exposure to the anti epileptic ...