Browsing Microbiology by Author "Boyd, Aoife"
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Bordetella pertussis expresses a functional type III secretion system that subverts protective innate and adaptive immune responses
Boyd, Aoife (American Society for Microbiology, 2008-01)Certain bacteria use a type III secretion system (TTSS) to deliver effector proteins that interfere with cell function into host cells. While transcription of genes encoding TTSS components has been demonstrated, studies ... -
Competition between the Yops of Yersinia enterocolitica for delivery into eukaryotic cells: Role of the SycE chaperone binding domain of YopE
Boyd, Aoife (American Society for Microbiology, 2000-09)A type III secretion-translocation system allows Yersinia adhering at the surface of animal cells to deliver a cocktail of effector Yops (YopH, -O, -P, -E, -M, and -T) into the cytosol of these cells. Residues or codons 1 ... -
Identification of Components of the Sigma B Regulon in Listeria monocytogenes That Contribute to Acid and Salt Tolerance
Boyd, Aoife; Abram, Florence; Karatzas, Kimon-andreas; Matlawska-Wasowska, Ksenia; Connolly, David; O'Byrne, Conor P.; Starr, Emily (American Society for Microbiology, 2008-09)Sigma B is an alternative sigma factor that controls the transcriptional response to stress in Listeria monocytogenes and is also known to play a role in the virulence of this human pathogen. In the present study we ... -
In vitro comparative cytotoxicity study of a novel biocidal iodo-thiocyanate complex
Tonoyan, Lilit; Boyd, Aoife; Fleming, Gerard T.A.; Friel, Ruairi; Gately, Carol M.; Mc Cay, Paul H.; O'Flaherty, Vincent (Elsevier, 2018-04-03)Novel biocides, which avoid the induction of cross-resistance to antibiotics, are an urgent societal requirement. Here, we compared the cytotoxic and bactericidal effects of a new antimicrobial agent, the iodo-thiocyanate ... -
LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells
Boyd, Aoife (American Society for Microbiology, 1998-06)Extracellular Yersinia disables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocolitica nonpolar lcrG mutant is severely impaired in the translocation of ... -
Manipulation of intestinal epithelial cell function by the cell contact-dependent type III secretion systems of Vibrio parahaemolyticus
O'Boyle, Nicky; Boyd, Aoife (Frontiers Media, 2014-01-10)Vibrio parahaemolyticus elicits gastroenteritis by deploying Type III Secretion Systems (TTSS) to deliver effector proteins into epithelial cells of the human intestinal tract. The bacteria must adhere to the human cells ... -
Pathogenic bacteria in our oceans' shellfish
Boyd, Aoife (Microbiology Society, 2019-02)Mussels, oysters, clams – some of the most appetising culinary dishes, such as moules-frites, feature shellfish. These foods are considered healthy as they are fresh from the ocean, but looks can be deceiving. -
Role of alginate lyase in cell detachment of Pseudomonas aeruginosa
Boyd, Aoife (American Society for Microbiology, 1994-07)The exopolysaccharide alginate of Pseudomonas aeruginosa was shown to be important in determining the degree of cell detachment from an agar surface. Nonmucoid strain 8822 gave rise to 50-fold more sloughed cells than ... -
The Vibrio parahaemolyticus ToxRS Regulator Is Required for Stress Tolerance and Colonization in a Novel Orogastric Streptomycin-Induced Adult Murine Model
Boyd, Aoife (American Society for Microbiology, 2012-03)Vibrio parahaemolyticus, a marine bacterium, is the causative agent of gastroenteritis associated with the consumption of seafood. It contains a homologue of the toxRS operon that in V. cholerae is the key regulator of ... -
The Vibrio parahaemolyticus Type III Secretion Systems manipulate host cell MAPK for critical steps in pathogenesis
Matlawska-Wasowska, Ksenia; Finn, Rebecca; Mustel, Ana; O'Byrne, Conor P.; Boyd, Aoife (BioMed Central, 2011)Background:Vibrio parahaemolyticus is a food-borne pathogen causing inflammation of the gastrointestinal epithelium. Pathogenic strains of this bacterium possess two Type III Secretion Systems (TTSS) that deliver effector ... -
The virulence plasmid of Yersinia, an anti-host genome
Boyd, Aoife (American Society for Microbiology, 1998-12)Invasive pathogenic bacteria have in common the capacity to overcome the defense mechanisms of their animal host and to proliferate in its tissues. They each have their own life-style and target organs and cause a variety ...