Browsing Externally hosted open access publications with University of Galway authors (1) by Subject "mammalian-cells"

Now showing items 1-3 of 3

    • Centrosome amplification induced by dna damage occurs during a prolonged g2 phase and involves atm 

      Dodson, Helen; Bourke, Emer; Jeffers, Liam J; Vagnarelli, Paola; Sonoda, Eiichiro; Takeda, Shunichi; Earnshaw, William C; Merdes, Andreas; Morrison, Ciaran (Wiley-Blackwell, 2004-09-09)
      Centrosomes are the principal microtubule organising centres in somatic cells. Abnormal centrosome number is common in tumours and occurs after gamma-irradiation and in cells with mutations in DNA repair genes. To investigate ...

    • Parp-1 protects homologous recombination from interference by ku and ligase iv in vertebrate cells 

      Hochegger, Helfrid; Dejsuphong, Donniphat; Fukushima, Toru; Morrison, Ciaran; Sonoda, Eiichiro; Schreiber, Valérie; Zhao, Guang Yu; Saberi, Alihossein; Masutani, Mitsuko; Adachi, Noritaka; Koyama, Hideki; de Murcia, Gilbert; Takeda, Shunichi (Wiley-Blackwell, 2006-02-23)
      Parp-1 and Parp-2 are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB). Their involvement in double-strand break (DSB) repair mediated by homologous recombination (HR) or ...

    • The rad30 cancer susceptibility gene 

      Carty, M.P.; Glynn, M.; Maher, M.; Smith, T.; Yao, J.; Dixon, K.; McCann, J.; Rynn, L.; Flanagan, A. (Portland Press Ltd., 2003-02-01)
      The human skin cancer-prone disease xeroderma pigmentosum variant (XPV) results from a mutation in RAD30, which encodes the novel lesion bypass DNA polymerase eta. XPV cells are characterized by delayed completion of DNA ...