Browsing Externally hosted open access publications with University of Galway authors (1) by Author "van den Bosch, Michael"

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    • The budding yeast rad9 checkpoint complex: chaperone proteins are required for its function 

      Gilbert, Christopher S; van den Bosch, Michael; Green, Catherine M; Vialard, Jorge E; Grenon, Muriel; Erdjument-Bromage, Hediye; Tempst, Paul; Lowndes, Noel F (Wiley-Blackwell, 2003-09-05)
      Rad9 functions in the DNA-damage checkpoint pathway of Saccharomyces cerevisiae. In whole-cell extracts, Rad9 is found in large, soluble complexes, which have functions in amplifying the checkpoint signal. The two main ...

    • The mrn complex: coordinating and mediating the response to broken chromosomes 

      van den Bosch, Michael; Bree, Ronan T.; Lowndes, Noel F. (Wiley-Blackwell, 2003-09-01)
      The MRE11-RAD50-NBS1 (MRN) protein complex has been linked to many DNA metabolic events that involve DNA double-stranded breaks (DSBs). In vertebrate cells, all three components are encoded by essential genes, and hypomorphic ...