Now showing items 1-3 of 3

    • Analysis of scc1-deficient cells defines a key metaphase role of vertebrate cohesin in linking sister kinetochores 

      Vagnarelli, Paola; Morrison, Ciaran; Dodson, Helen; Sonoda, Eiichiro; Takeda, Shunichi; Earnshaw, William C (Wiley-Blackwell, 2004-02-01)
      Cleavage of the cohesin subunit Scc1p/Mcd1p/Rad21 permits sister chromatid separation and is considered to trigger anaphase onset. It has also been suggested that the cohesin complex is essential for chromosome condensation ...
    • Centrosome amplification induced by dna damage occurs during a prolonged g2 phase and involves atm 

      Dodson, Helen; Bourke, Emer; Jeffers, Liam J; Vagnarelli, Paola; Sonoda, Eiichiro; Takeda, Shunichi; Earnshaw, William C; Merdes, Andreas; Morrison, Ciaran (Wiley-Blackwell, 2004-09-09)
      Centrosomes are the principal microtubule organising centres in somatic cells. Abnormal centrosome number is common in tumours and occurs after gamma-irradiation and in cells with mutations in DNA repair genes. To investigate ...
    • Parp-1 protects homologous recombination from interference by ku and ligase iv in vertebrate cells 

      Hochegger, Helfrid; Dejsuphong, Donniphat; Fukushima, Toru; Morrison, Ciaran; Sonoda, Eiichiro; Schreiber, Valérie; Zhao, Guang Yu; Saberi, Alihossein; Masutani, Mitsuko; Adachi, Noritaka; Koyama, Hideki; de Murcia, Gilbert; Takeda, Shunichi (Wiley-Blackwell, 2006-02-23)
      Parp-1 and Parp-2 are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB). Their involvement in double-strand break (DSB) repair mediated by homologous recombination (HR) or ...