dc.contributor.author | Milcovich, Gesmi | |
dc.contributor.author | Contessotto, Paolo | |
dc.contributor.author | Marsico, Grazia | |
dc.contributor.author | Ismail, Siti | |
dc.contributor.author | Pandit, Abhay | |
dc.date.accessioned | 2017-11-20T14:44:25Z | |
dc.date.available | 2017-11-20T14:44:25Z | |
dc.date.issued | 2017-10-13 | |
dc.identifier.citation | Milcovich, Gesmi, Contessotto, Paolo, Marsico, Grazia, Ismail, Siti, & Pandit, Abhay. (2017). Synthetic/ECM-inspired hybrid platform for hollow microcarriers with ROS-triggered nanoporation hallmarks. Scientific Reports, 7(1), 13138. doi: 10.1038/s41598-017-13744-y | en_IE |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/10379/6974 | |
dc.description.abstract | Reactive oxygen species (ROS) are key pathological signals expressed in inflammatory diseases such as cancer, ischemic conditions and atherosclerosis. An ideal drug delivery system should not only be responsive to these signals but also should not elicit an unfavourable host response. This study presents an innovative platform for drug delivery where a natural/synthetic composite system composed of collagen type I and a synthesized polythioether, ensures a dual stimuli-responsive behaviour. Collagen type I is an extracellular matrix constituent protein, responsive to matrix metalloproteinases (MMP) cleavage per se. Polythioethers are stable synthetic polymers characterized by the presence of sulphur, which undergoes a ROS-responsive swelling switch. A polythioether was synthesised, functionalized and tested for cytotoxicity. Optimal conditions to fabricate a composite natural/synthetic hollow sphere construct were optimised by a template-based method. Collagen-polythioether hollow spheres were fabricated, revealing uniform size and ROS-triggered nanoporation features. Cellular metabolic activity of H9C2 cardiomyoblasts remained unaffected upon exposure to the spheres. Our natural/synthetic hollow microspheres exhibit the potential for use as a pathological stimuli-responsive reservoir system for applications in inflammatory diseases. | en_IE |
dc.description.sponsorship | This material is based upon works supported by the European Union funding under the AngioMatTrain 7th Framework Programme, Grant Agreement Number 317304. This publication has emanated from research supported in part by a research grant from Science Foundation Ireland (SFI) and is co-funded under the European Regional Development Fund under Grant Number 13/RC/2073. The authors acknowledge the use of the facilities and the scientific and technical assistance of the Centre for Microscopy and Imaging at the National University of Ireland Galway (www.imagingnuigalway.ie), a facility that is co-funded by the Irish Government’s Programme for Research in Third Level Institutions, Cycles 4 and 5, National Development Plan 2007–2013. | en_IE |
dc.format | application/pdf | en_IE |
dc.language.iso | en | en_IE |
dc.publisher | Nature Publishing Group | en_IE |
dc.relation.ispartof | Scientific Reports | en |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | REACTIVE OXYGEN | en_IE |
dc.subject | BIOMEDICAL APPLICATIONS | en_IE |
dc.subject | HYPOXIA-REOXYGENATION | en_IE |
dc.subject | DELIVERY | en_IE |
dc.subject | NANOPARTICLES | en_IE |
dc.subject | DEGRADATION | en_IE |
dc.subject | RELEASE | en_IE |
dc.subject | CARDIOMYOCYTES | en_IE |
dc.subject | RESPONSIVENESS | en_IE |
dc.subject | NANOMATERIALS | en_IE |
dc.subject | ROS (Reactive Oxygen Species) | en_IE |
dc.subject | Inflamed tissue | en_IE |
dc.subject | Stimuli-responsive | en_IE |
dc.subject | Biomaterials | en_IE |
dc.subject | Ischemic conditions | en_IE |
dc.subject | Hollow spheres | en_IE |
dc.subject | Polysulfides | en_IE |
dc.subject | Collagen | en_IE |
dc.title | Synthetic/ECM-inspired hybrid platform for hollow microcarriers with ROS-triggered nanoporation hallmarks | en_IE |
dc.type | Article | en_IE |
dc.date.updated | 2017-11-20T13:47:52Z | |
dc.identifier.doi | 10.1038/s41598-017-13744-y | |
dc.local.publishedsource | http://dx.doi.org/10.1038/s41598-017-13744-y | en_IE |
dc.description.peer-reviewed | peer-reviewed | |
dc.contributor.funder | |~| | |
dc.internal.rssid | 13352032 | |
dc.local.contact | Abhay Shashikant Pandit, Curam, Biomedical Sciences, Nui Galway. 2758 Email: abhay.pandit@oegaillimh.ie | |
dc.local.copyrightchecked | Yes | |
dc.local.version | ACCEPTED | |
nui.item.downloads | 606 | |