Show simple item record

dc.contributor.authorMilcovich, Gesmi
dc.contributor.authorContessotto, Paolo
dc.contributor.authorMarsico, Grazia
dc.contributor.authorIsmail, Siti
dc.contributor.authorPandit, Abhay
dc.date.accessioned2017-11-20T14:44:25Z
dc.date.available2017-11-20T14:44:25Z
dc.date.issued2017-10-13
dc.identifier.citationMilcovich, Gesmi, Contessotto, Paolo, Marsico, Grazia, Ismail, Siti, & Pandit, Abhay. (2017). Synthetic/ECM-inspired hybrid platform for hollow microcarriers with ROS-triggered nanoporation hallmarks. Scientific Reports, 7(1), 13138. doi: 10.1038/s41598-017-13744-yen_IE
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10379/6974
dc.description.abstractReactive oxygen species (ROS) are key pathological signals expressed in inflammatory diseases such as cancer, ischemic conditions and atherosclerosis. An ideal drug delivery system should not only be responsive to these signals but also should not elicit an unfavourable host response. This study presents an innovative platform for drug delivery where a natural/synthetic composite system composed of collagen type I and a synthesized polythioether, ensures a dual stimuli-responsive behaviour. Collagen type I is an extracellular matrix constituent protein, responsive to matrix metalloproteinases (MMP) cleavage per se. Polythioethers are stable synthetic polymers characterized by the presence of sulphur, which undergoes a ROS-responsive swelling switch. A polythioether was synthesised, functionalized and tested for cytotoxicity. Optimal conditions to fabricate a composite natural/synthetic hollow sphere construct were optimised by a template-based method. Collagen-polythioether hollow spheres were fabricated, revealing uniform size and ROS-triggered nanoporation features. Cellular metabolic activity of H9C2 cardiomyoblasts remained unaffected upon exposure to the spheres. Our natural/synthetic hollow microspheres exhibit the potential for use as a pathological stimuli-responsive reservoir system for applications in inflammatory diseases.en_IE
dc.description.sponsorshipThis material is based upon works supported by the European Union funding under the AngioMatTrain 7th Framework Programme, Grant Agreement Number 317304. This publication has emanated from research supported in part by a research grant from Science Foundation Ireland (SFI) and is co-funded under the European Regional Development Fund under Grant Number 13/RC/2073. The authors acknowledge the use of the facilities and the scientific and technical assistance of the Centre for Microscopy and Imaging at the National University of Ireland Galway (www.imagingnuigalway.ie), a facility that is co-funded by the Irish Government’s Programme for Research in Third Level Institutions, Cycles 4 and 5, National Development Plan 2007–2013.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherNature Publishing Groupen_IE
dc.relation.ispartofScientific Reportsen
dc.subjectREACTIVE OXYGENen_IE
dc.subjectBIOMEDICAL APPLICATIONSen_IE
dc.subjectHYPOXIA-REOXYGENATIONen_IE
dc.subjectDELIVERYen_IE
dc.subjectNANOPARTICLESen_IE
dc.subjectDEGRADATIONen_IE
dc.subjectRELEASEen_IE
dc.subjectCARDIOMYOCYTESen_IE
dc.subjectRESPONSIVENESSen_IE
dc.subjectNANOMATERIALSen_IE
dc.subjectROS (Reactive Oxygen Species)en_IE
dc.subjectInflamed tissueen_IE
dc.subjectStimuli-responsiveen_IE
dc.subjectBiomaterialsen_IE
dc.subjectIschemic conditionsen_IE
dc.subjectHollow spheresen_IE
dc.subjectPolysulfidesen_IE
dc.subjectCollagenen_IE
dc.titleSynthetic/ECM-inspired hybrid platform for hollow microcarriers with ROS-triggered nanoporation hallmarksen_IE
dc.typeArticleen_IE
dc.date.updated2017-11-20T13:47:52Z
dc.identifier.doi10.1038/s41598-017-13744-y
dc.local.publishedsourcehttp://dx.doi.org/10.1038/s41598-017-13744-yen_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid13352032
dc.local.contactAbhay Shashikant Pandit, Curam, Biomedical Sciences, Nui Galway. 2758 Email: abhay.pandit@oegaillimh.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
nui.item.downloads275


Files in this item

Attribution-NonCommercial-NoDerivs 3.0 Ireland
This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. Please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.

The following license files are associated with this item:

Thumbnail

This item appears in the following Collection(s)

Show simple item record