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dc.contributor.authorO'Boyle, Nicky
dc.contributor.authorBoyd, Aoife
dc.identifier.citationO'Boyle, Nicky, & Boyd, Aoife. (2014). Manipulation of intestinal epithelial cell function by the cell contact-dependent type III secretion systems of Vibrio parahaemolyticus. Frontiers in Cellular and Infection Microbiology, 3(114). doi: 10.3389/fcimb.2013.00114en_IE
dc.description.abstractVibrio parahaemolyticus elicits gastroenteritis by deploying Type III Secretion Systems (TTSS) to deliver effector proteins into epithelial cells of the human intestinal tract. The bacteria must adhere to the human cells to allow colonization and operation of the TTSS translocation apparatus bridging the bacterium and the host cell. This article first reviews recent advances in identifying the molecules responsible for intercellular adherence. V parahaemolyticus possesses two TTSS, each of which delivers an exclusive set of effectors and mediates unique effects on the host cell. TTSS effectors primarily target and alter the activation status of host cell signaling proteins, thereby bringing about changes in the regulation of cellular behavior. TTSS1 is responsible for the cytotoxicity of V parahaemolyticus, while TTSS2 is necessary for the enterotoxicity of the pathogen. Recent publications have elucidated the function of several TTSS effectors and their importance in the virulence of the bacterium. This review will explore the ability of the TTSS to manipulate activities of human intestinal cells and how this modification of cell function favors bacterial colonization and persistence of V parahaemolyticus in the host.en_IE
dc.description.sponsorshipNicky O'Boyle was supported by Science Foundation Ireland, grant no. 08/RFP/GEN1225 to the Pathogenic Mechanisms Research Group, NUI Galway.en_IE
dc.publisherFrontiers Mediaen_IE
dc.relation.ispartofFrontiers In Cellular And Infection Microbiologyen
dc.subjectVibrio parahaemolyticusen_IE
dc.subjectIntestinal cellsen_IE
dc.subjectMannose sensitive hemagglutininen_IE
dc.subjectAdhesion molecule 7en_IE
dc.subjectThermostable direct hemolysinen_IE
dc.subjectActin filament nucleationen_IE
dc.subjectBacterial effector VOPLen_IE
dc.subjectCholerae el toren_IE
dc.subjectHost cellen_IE
dc.subjectColonization factoren_IE
dc.subjectBiofilm formationen_IE
dc.subjectBinding domainen_IE
dc.titleManipulation of intestinal epithelial cell function by the cell contact-dependent type III secretion systems of Vibrio parahaemolyticusen_IE
dc.local.contactAoife Boyd, Dept. Of Microbiology, Arts/Science Building, Nui Galway. 2404 Email:

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