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dc.contributor.authorHu, Yun
dc.contributor.authorErxleben, Andrea
dc.contributor.authorHodnett, Kieran
dc.contributor.authorLi, Boyan
dc.contributor.authorMcArdle, Patrick
dc.contributor.authorRasmuson, Åke C.
dc.contributor.authorRyder, Alan G.
dc.date.accessioned2017-05-25T13:47:48Z
dc.date.available2017-05-25T13:47:48Z
dc.date.issued2013-07-11
dc.identifier.citationHu, Yun, Erxleben, Andrea, Hodnett, B. Kieran, Li, Boyan, McArdle, Patrick, Rasmuson, Åke C., & Ryder, Alan G. (2013). Solid-State Transformations of Sulfathiazole Polymorphs: The Effects of Milling and Humidity. Crystal Growth & Design, 13(8), 3404-3413. doi: 10.1021/cg4002779en_IE
dc.identifier.issn1528-7505
dc.identifier.urihttp://hdl.handle.net/10379/6547
dc.description.abstractThe effect of milling on the transitions of sulfathiazole polymorphs in the absence and presence of solvent and excipients was monitored by X-ray powder diffraction (XRPD), attenuated total reflectance infrared (ATR-IR), and near-infrared (NIR) spectroscopy. Sulfathiazole forms FII-FV undergo a transformation toward the metastable FI, which involves an intermediate amorphous stage upon milling at ambient temperature. Milling the commercial form (FC) with catalytic amounts of solvent converts it to pure FIV or to mixtures of FI and FIV depending on the solvent used. Pure FIV can be easily prepared from FC by this method. The physical stability of nonmechanically activated pure sulfathiazole forms in the presence of different levels of relative humidity (RH) was also investigated. At low RH, all sulfathiazole forms are kinetically stable, but at RH levels above 70% FII, FC and FIV remain stable, while FI and FV transform to mixtures of FII and FIV without any apparent change in the external form of the crystals. Comilling FC with a range of excipients gave results that depended on the excipient used, and comilling with cellulose gave samples that had an amorphous content that was stable at 10% RH for at least nine months at ambient temperature.en_IE
dc.description.sponsorshipThis work was supported by Science Foundation Ireland under Grant No. [07/SRC/B1158] as part of the Solid State Pharmaceutical Cluster (SSPC).en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherAmerican Chemical Societyen_IE
dc.relation.ispartofCrystal Growth & Designen
dc.subjectNear infrared spectroscopyen_IE
dc.subjectMechanical activationen_IE
dc.subjectPhase transformationsen_IE
dc.subjectRaman spectroscopyen_IE
dc.subjectQuantificationen_IE
dc.subjectAmorphizationen_IE
dc.subjectTemperatureen_IE
dc.subjectTransitionen_IE
dc.subjectFormsen_IE
dc.subjectCalorimetryen_IE
dc.titleSolid-state transformations of sulfathiazole polymorphs: The effects of milling and humidityen_IE
dc.typeArticleen_IE
dc.date.updated2017-05-19T07:33:17Z
dc.identifier.doi10.1021/cg4002779
dc.local.publishedsourcehttp://dx.doi.org/10.1021/cg4002779en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid4999699
dc.local.contactAndrea Erxleben, School Of Chemistry, Room 150, Arts/Science Building, Nui Galway. 2483 Email: andrea.erxleben@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionACCEPTED
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