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dc.contributor.authorMacFhionnghaile, Pól
dc.contributor.authorHu, Yun
dc.contributor.authorGniado, Katarzyna
dc.contributor.authorCurran, Sinead
dc.contributor.authorMcArdle, Patrick
dc.contributor.authorErxleben, Andrea
dc.date.accessioned2017-05-25T10:34:34Z
dc.date.available2017-05-25T10:34:34Z
dc.date.issued2014-04-11
dc.identifier.citationMacFhionnghaile, Pól, Hu, Yun, Gniado, Katarzyna, Curran, Sinead, McArdle, Patrick, & Erxleben, Andrea. (2014). Effects of Ball-Milling and Cryomilling on Sulfamerazine Polymorphs: A Quantitative Study. Journal of Pharmaceutical Sciences, 103(6), 1766-1778. doi: https://doi.org/10.1002/jps.23978en_IE
dc.identifier.issn1520-6017
dc.identifier.urihttp://hdl.handle.net/10379/6545
dc.description.abstractThe effects of ball-milling and cryomilling on sulfamerazine forms I and II (SMZ FI, FII) were investigated using X-ray powder diffraction, infrared and near-infrared (NIR) spectroscopy. Cryomilling resulted in a complete amorphization of both polymorphs. Milling at room temperature gave mixtures of amorphous SMZ (FA) and FII. Calibration models were developed for the quantitative analysis of binary (FI/FII, FI/FA, and FII/FA) and ternary (FI/FII/FA) mixtures using NIR spectroscopy combined with partial least-squares (PLS) regression. The PLS models for binary (0%-100%), ternary (0%-100%), and low-level (0%-10%) binary mixtures had root-mean-square errors of prediction of 1.8%, 5.1%, and 0.80%, respectively. The calibration models were used to obtain a detailed quantitative picture of solid-state transformations during milling and any subsequent recrystallizations. FA prepared by cryomilling FI for less than 60 min recrystallized to mixtures of FI and FII, whereas samples milled for more than 60 min crystallized to pure FII. The effect of comilling SMZ with stoichiometric amounts of additives was investigated. SMZ formed amorphous materials with oxalic, dl-tartaric, and citric acids that were more stable toward recrystallization than FA. Amorphous SMZ/oxalic acid was found to recrystallize to a 2:1 cocrystal during storage. (c) 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Scien_IE
dc.description.sponsorshipThis work was supported by Science Foundation Ireland under Grant No. [07/SRC/B1158] as part of the Solid State Pharmaceutical Cluster (SSPC). Mr. Dermot McGrath is thanked for DSC measurements.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofJournal Of Pharmaceutical Sciencesen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectX-ray powder diffractometryen_IE
dc.subjectAmorphousen_IE
dc.subjectNear-infrared spectroscopyen_IE
dc.subjectStabilityen_IE
dc.subjectMultivariate analysisen_IE
dc.subjectNear infrared spectroscopyen_IE
dc.subjectSolid state amorphizationen_IE
dc.subjectProcess induced disorderen_IE
dc.subjectRay powder diffractionen_IE
dc.subjectPhysical stabilityen_IE
dc.subjectRanitidine hydrochlorideen_IE
dc.subjectRaman spectroscopyen_IE
dc.subjectCrystal structureen_IE
dc.subjectMolecular complexesen_IE
dc.subjectAmorphous phaseen_IE
dc.titleEffects of ball-milling and cryomilling on sulfamerazine polymorphs: A quantitative studyen_IE
dc.typeArticleen_IE
dc.date.updated2017-05-19T07:28:54Z
dc.identifier.doi10.1002/jps.23978
dc.local.publishedsourcehttps://doi.org/10.1002/jps.23978en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid6611277
dc.local.contactAndrea Erxleben, School Of Chemistry, Room 150, Arts/Science Building, Nui Galway. 2483 Email: andrea.erxleben@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionACCEPTED
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