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dc.contributor.authorTabrizi, Leila
dc.contributor.authorMcArdle, Patrick
dc.contributor.authorErxleben, Andrea
dc.contributor.authorChiniforoshan, Hossein
dc.date.accessioned2017-05-24T13:08:58Z
dc.date.issued2015-09-25
dc.identifier.citationTabrizi, Leila, McArdle, Patrick, Erxleben, Andrea, & Chiniforoshan, Hossein. (2015). Cytotoxicity and antimicrobial activity of triorganotin(IV) complexes of phenylcyanamide prepared by sonochemical synthesis. Inorganica Chimica Acta, 438, 94-104. doi: https://doi.org/10.1016/j.ica.2015.09.011en_IE
dc.identifier.issn0020-1693
dc.identifier.urihttp://hdl.handle.net/10379/6543
dc.description.abstractThis article describes the synthesis and characterization of novel triorganotin(IV) complexes and their potential medicinal applications. Triorganotin(IV) complexes with formulas [(SnMe3)(2)(mu-bp)(H2O)(2)], 1, and [(SnMe3)(4-NO(2)pcyd)], 2, (Me: methyl, bpH(2): 4,4'-dicyanamidobiphenyl and 4-NO(2)pcyd: 4-nitrophenylcyanamide) have been synthesized via a sonochemical process and characterized using multinuclear NMR (H-1, C-13 and Sn-119), Mossbauer spectroscopy, elemental analysis, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Compounds 1 and 2 were evaluated for their DNA/protein binding with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA), respectively. The in vitro cytotoxicity of 1 and 2 was examined against A549, Du145, HeLa and MCF-7 cancer cell lines. For 1, a promising growth inhibitory effect against HeLa cells was observed that is slightly higher than that of cisplatin. Moreover, the antimicrobial activity of 1 and 2 against different strains of pathogenic bacteria and fungi were tested. The free radical scavenging ability (OH, NO) of 1 and 2 was assessed. (C) 2015 Elsevier B.V. All rights reserved.en_IE
dc.description.sponsorshipWe are grateful for the financial support from the Department of Chemistry, Isfahan University Of Technology (IUT).en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofInorganica Chimica Actaen
dc.subjectTriorganotin phenylcyanamideen_IE
dc.subjectDNA bindingen_IE
dc.subjectBSA bindingen_IE
dc.subjectAntioxidant activityen_IE
dc.subjectCytotoxicityen_IE
dc.subjectBovine serum albuminen_IE
dc.subjectBovine serum-albuminen_IE
dc.subjectIn-vitro cytotoxicityen_IE
dc.subjectTridentate schiff-baseen_IE
dc.subjectDNA-binding propertiesen_IE
dc.subjectSN-119 nmr-spectraen_IE
dc.subjectX-ray-diffractionen_IE
dc.subjectCalf thymus DNAen_IE
dc.subjectState C-13 NMRen_IE
dc.subjectSN-ME angleen_IE
dc.subjectCrystal -structureen_IE
dc.titleCytotoxicity and antimicrobial activity of triorganotin(IV) complexes of phenylcyanamide prepared by sonochemical synthesisen_IE
dc.typeArticleen_IE
dc.date.updated2017-05-18T12:51:24Z
dc.identifier.doi10.1016/j.ica.2015.09.011
dc.local.publishedsourcehttps://doi.org/10.1016/j.ica.2015.09.011en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.description.embargo2017-09-25
dc.internal.rssid10170602
dc.local.contactAndrea Erxleben, School Of Chemistry, Room 150, Arts/Science Building, Nui Galway. 2483 Email: andrea.erxleben@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionACCEPTED
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