Show simple item record

dc.contributor.authorKamali, Naghmeh
dc.contributor.authorAljohani, Marwah
dc.contributor.authorMcArdle, Patrick
dc.contributor.authorErxleben, Andrea
dc.date.accessioned2017-05-23T14:14:58Z
dc.date.available2017-05-23T14:14:58Z
dc.date.issued2015-07-14
dc.identifier.citationKamali, Naghmeh, Aljohani, Marwah, McArdle, Patrick, & Erxleben, Andrea. (2015). Hydrogen Bonding Networks and Solid-State Conversions in Benzamidinium Salts. Crystal Growth & Design, 15(8), 3905-3916. doi: 10.1021/acs.cgd.5b00529en_IE
dc.identifier.issn1528-7505
dc.identifier.urihttp://hdl.handle.net/10379/6539
dc.description.abstractTen benzamidinium salts of carboxylic acids, amides, and sulfonamides have been crystallized from solution. Single-crystal X-ray analyses revealed various hydrogen bonding motifs which ate discussed in terms of supramolecular synthons and graph sets. Benzamidinium hydrogen maleate (5a) crystallizes as large,needles of up to >3 cm in length. Attempts to influence the crystal habit and size through a change of solvent and the presence of additives yielded a second polymorph (5b). The formation of the benzamidinium Salts by mechanochemical reaction Was also investigated. Grinding of benzamidine with nicotinic acid, salicylic acid, p-aminobenzoic acid, cyanuric acid, pimelic acid, saccharin, and sulfathiazole with mortar and pestle or using a ball-mill gave compounds identical to those obtained by crystallization from solution: Time-dependent X-ray powder patterns of a stoichiometric benzamidine/cyanuric acid mixture suggested that the mechanochemical salt formation occurred via the amorphous state. Ball-milling of benzamidine with sulfamerazine generated amorphous benzamidinium sulfamerazinate that was stable toward crystallization for at least 2 weeks, when stored at 25% relative humidity.en_IE
dc.description.sponsorshipThis work was supported by Science Foundation Ireland under Grant No. [07/SRC/B1158] as part of the Synthesis and Solid State Pharmaceutical Centre (SSPC).en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.relation.ispartofCrystal Growth & Designen
dc.subjectCrystal structureen_IE
dc.subjectGlycosidase inhibitorsen_IE
dc.subjectMannosidase inhibitorsen_IE
dc.subjectTransition stateen_IE
dc.subjectMalonate IIen_IE
dc.subjectAmidineen_IE
dc.subjectSulfamerazineen_IE
dc.subjectPotenten_IE
dc.subjectMechanochemistryen_IE
dc.subjectDerivativesen_IE
dc.titleHydrogen bonding networks and solid-state conversions in benzamidinium saltsen_IE
dc.typeArticleen_IE
dc.date.updated2017-05-18T09:05:51Z
dc.identifier.doi10.1021/acs.cgd.5b00529
dc.local.publishedsourcehttp://dx.doi.org/10.1021/acs.cgd.5b00529en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid9423831
dc.local.contactAndrea Erxleben, School Of Chemistry, Room 150, Arts/Science Building, Nui Galway. 2483 Email: andrea.erxleben@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionACCEPTED
nui.item.downloads69


Files in this item

Attribution-NonCommercial-NoDerivs 3.0 Ireland
This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. Please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.

The following license files are associated with this item:

Thumbnail

This item appears in the following Collection(s)

Show simple item record