dc.contributor.author | Kamali, Naghmeh | |
dc.contributor.author | Aljohani, Marwah | |
dc.contributor.author | McArdle, Patrick | |
dc.contributor.author | Erxleben, Andrea | |
dc.date.accessioned | 2017-05-23T14:14:58Z | |
dc.date.available | 2017-05-23T14:14:58Z | |
dc.date.issued | 2015-07-14 | |
dc.identifier.citation | Kamali, Naghmeh, Aljohani, Marwah, McArdle, Patrick, & Erxleben, Andrea. (2015). Hydrogen Bonding Networks and Solid-State Conversions in Benzamidinium Salts. Crystal Growth & Design, 15(8), 3905-3916. doi: 10.1021/acs.cgd.5b00529 | en_IE |
dc.identifier.issn | 1528-7505 | |
dc.identifier.uri | http://hdl.handle.net/10379/6539 | |
dc.description.abstract | Ten benzamidinium salts of carboxylic acids, amides, and sulfonamides have been crystallized from solution. Single-crystal X-ray analyses revealed various hydrogen bonding motifs which ate discussed in terms of supramolecular synthons and graph sets. Benzamidinium hydrogen maleate (5a) crystallizes as large,needles of up to >3 cm in length. Attempts to influence the crystal habit and size through a change of solvent and the presence of additives yielded a second polymorph (5b). The formation of the benzamidinium Salts by mechanochemical reaction Was also investigated. Grinding of benzamidine with nicotinic acid, salicylic acid, p-aminobenzoic acid, cyanuric acid, pimelic acid, saccharin, and sulfathiazole with mortar and pestle or using a ball-mill gave compounds identical to those obtained by crystallization from solution: Time-dependent X-ray powder patterns of a stoichiometric benzamidine/cyanuric acid mixture suggested that the mechanochemical salt formation occurred via the amorphous state. Ball-milling of benzamidine with sulfamerazine generated amorphous benzamidinium sulfamerazinate that was stable toward crystallization for at least 2 weeks, when stored at 25% relative humidity. | en_IE |
dc.description.sponsorship | This work was supported by Science Foundation Ireland under Grant No. [07/SRC/B1158] as part of the Synthesis and Solid State Pharmaceutical Centre (SSPC). | en_IE |
dc.format | application/pdf | en_IE |
dc.language.iso | en | en_IE |
dc.relation.ispartof | Crystal Growth & Design | en |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | Crystal structure | en_IE |
dc.subject | Glycosidase inhibitors | en_IE |
dc.subject | Mannosidase inhibitors | en_IE |
dc.subject | Transition state | en_IE |
dc.subject | Malonate II | en_IE |
dc.subject | Amidine | en_IE |
dc.subject | Sulfamerazine | en_IE |
dc.subject | Potent | en_IE |
dc.subject | Mechanochemistry | en_IE |
dc.subject | Derivatives | en_IE |
dc.title | Hydrogen bonding networks and solid-state conversions in benzamidinium salts | en_IE |
dc.type | Article | en_IE |
dc.date.updated | 2017-05-18T09:05:51Z | |
dc.identifier.doi | 10.1021/acs.cgd.5b00529 | |
dc.local.publishedsource | http://dx.doi.org/10.1021/acs.cgd.5b00529 | en_IE |
dc.description.peer-reviewed | peer-reviewed | |
dc.contributor.funder | |~| | |
dc.internal.rssid | 9423831 | |
dc.local.contact | Andrea Erxleben, School Of Chemistry, Room 150, Arts/Science Building, Nui Galway. 2483 Email: andrea.erxleben@nuigalway.ie | |
dc.local.copyrightchecked | No | |
dc.local.version | ACCEPTED | |
nui.item.downloads | 512 | |