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dc.contributor.authorMariotti, Letizia
dc.contributor.authorDevaney, Nicholas
dc.contributor.authorLombardo, Giuseppe
dc.contributor.authorLombardo, Marco
dc.date.accessioned2017-02-16T11:55:11Z
dc.date.available2017-02-16T11:55:11Z
dc.date.issued2016
dc.identifier.citationMariotti, L,Devaney, N,Lombardo, G,Lombardo, M (2016) 'Understanding the changes of cone reflectance in adaptive optics flood illumination retinal images over three years'. Biomedical Optics Express, 7 :2807-2822.en_IE
dc.identifier.issn2156-7085
dc.identifier.urihttp://hdl.handle.net/10379/6314
dc.description.abstractAlthough there is increasing interest in the investigation of cone reflectance variability, little is understood about its characteristics over long time scales. Cone detection and its automation is now becoming a fundamental step in the assessment and monitoring of the health of the retina and in the understanding of the photoreceptor physiology. In this work we provide an insight into the cone reflectance variability over time scales ranging from minutes to three years on the same eye, and for large areas of the retina (>= 2.0 x 2.0 degrees) at two different retinal eccentricities using a commercial adaptive optics (AO) flood illumination retinal camera. We observed that the difference in reflectance observed in the cones increases with the time separation between the data acquisitions and this may have a negative impact on algorithms attempting to track cones over time. In addition, we determined that displacements of the light source within 0.35 mm of the pupil center, which is the farthest location from the pupil center used by operators of the AO camera to acquire high-quality images of the cone mosaic in clinical studies, does not significantly affect the cone detection and density estimation. (C) 2016 Optical Society of Americaen_IE
dc.description.sponsorshipResearch for this work was supported by the Irish Research Council (GOIPG/2013/775), the National Framework Program for Research and Innovation PON (grant n. 01 00110), the Italian Ministry of Health (grant 5×1000) and Fondazione Roma.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherOptical Society of Americaen_IE
dc.relation.ispartofBiomedical Optics Expressen
dc.subjectPhysicsen_IE
dc.subjectIn vivoen_IE
dc.subjectCoherenceen_IE
dc.subjectTomographyen_IE
dc.subjectParafoveal conesen_IE
dc.subjectPhotoreceptorsen_IE
dc.subjectRegistrationen_IE
dc.subjectSensitivityen_IE
dc.subjectDensityen_IE
dc.titleUnderstanding the changes of cone reflectance in adaptive optics flood illumination retinal images over three yearsen_IE
dc.typeArticleen_IE
dc.date.updated2017-02-16T11:43:02Z
dc.identifier.doi10.1364/BOE.7.002807
dc.local.publishedsourcehttps://doi.org/10.1364/BOE.7.002807en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid11346736
dc.local.contactNicholas Devaney, School Of Physics, Nuig. 5188 Email: nicholas.devaney@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionACCEPTED
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