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dc.contributor.authorIslam, Md Nahidul
dc.contributor.authorBradley, Benjamin A.
dc.contributor.authorCeredig, Rhodri
dc.identifier.citationIslam, Md Nahidul, Bradley, Benjamin A., & Ceredig, Rhodri. (2016). Sterile post-traumatic immunosuppression. Clin Trans Immunol, 5, e77. doi: 10.1038/cti.2016.13en_IE
dc.description.abstractAfter major trauma, the human immune system initiates a series of inflammatory events at the injury site that is later followed by suppression of local inflammation favoring the repair and remodeling of the damaged tissues. This local immune response involves complex interactions between resident cells such as macrophages and dendritic cells, soluble mediators such as cytokines and chemokines, and recruited cells such as neutrophils, monocytes and mesenchymal stromal cells. If of sufficient magnitude, these initial immune responses nevertheless have systemic consequences resulting in a state called post-traumatic immunosuppression (PTI). However, controversy exists regarding the exact immunological changes occurring in systemic compartments triggered by these local immune responses. PTI is one of the leading causes of post-surgical mortality and makes patients vulnerable to hospital-acquired infections, multiple organ failure and many other complications. In addition, hemorrhage, blood transfusion, immunesenescence and immunosuppressant drugs aggravate PTI. PTI has been intensively studied, but published results are frequently cloudy. The purpose of this review is to focus on the contributions made by different responsive modalities to immunosuppression following sterile trauma and to try to integrate these into an overall scheme of PTI.en_IE
dc.description.sponsorshipThis work was supported by Science Foundation Ireland under grant numbers SFI09/SRC/B1794 (to RC) and by a Science Foundation Ireland Stokes Professorship SFI07/SK/B1233b (to RC). NI obtained financial support from the Irish Research Council—EMBARK Award (RS/2011/223).en_IE
dc.publisherNature Publishing Groupen_IE
dc.relation.ispartofClinical & Translational Immunologyen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.subjectPost-traumatic immunosuppression (PTI)en_IE
dc.subjectRegenerative medicineen_IE
dc.titleSterile post-traumatic immunosuppressionen_IE
dc.local.contactRhodri Ceredig, Room 217, Orbsen Building, Nui Galway. 5916 Email:

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