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dc.contributor.authorDoyle, Heather
dc.contributor.authorLohfeld, Stefan
dc.contributor.authorDurselen, Lutz
dc.contributor.authorMcHugh, Peter
dc.date.accessioned2017-01-20T09:40:29Z
dc.date.available2017-01-20T09:40:29Z
dc.date.issued2015-01-14
dc.identifier.citationDoyle, Heather, Lohfeld, Stefan, Dürselen, Lutz, & McHugh, Peter. (2015). Computational modelling of ovine critical-sized tibial defects with implanted scaffolds and prediction of the safety of fixator removal. Journal of the Mechanical Behavior of Biomedical Materials, 44, 133-146. doi: http://dx.doi.org/10.1016/j.jmbbm.2015.01.008en_IE
dc.identifier.issn1878-0180
dc.identifier.urihttp://hdl.handle.net/10379/6259
dc.description.abstractComputational model geometries of tibial defects with two types of implanted tissue engineering scaffolds, β-tricalcium phosphate (β-TCP) and poly-ε-caprolactone (PCL)/β-TCP, are constructed from µ-CT scan images of the real in vivo defects. Simulations of each defect under four-point bending and under simulated in vivo axial compressive loading are performed. The mechanical stability of each defect is analysed using stress distribution analysis. The results of this analysis highlights the influence of callus volume, and both scaffold volume and stiffness, on the load-bearing abilities of these defects. Clinically-used image-based methods to predict the safety of removing external fixation are evaluated for each defect. Comparison of these measures with the results of computational analyses indicates that care must be taken in the interpretation of these measures.en_IE
dc.description.sponsorshipH. Doyle acknowledges funding from the Irish Research Council under the Embark Initiative Postgraduate Research Scholarship Scheme, and the SFI/HEA Irish Centre for High-End Computing (ICHEC) for the provision of computational facilities and support. The authors acknowledge research funding from the European Union through the STEPS FP6 Project (contract number FP6-500465) and also the partners in the STEPS project for their input.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofJournal Of Mechanical Behaviour Of Biomedical Materialsen
dc.subjectOrthopaedic scaffolden_IE
dc.subjectPCLen_IE
dc.subjectCritical sized defecten_IE
dc.subjectDefect stabilityen_IE
dc.subjectBeta-tricalcium phosphateen_IE
dc.subjectβ-tricalcium phosphateen_IE
dc.subjectExternal fixatoren_IE
dc.subjectQuantitative computed tomographyen_IE
dc.subjectFracture healing processen_IE
dc.subjectFinite element analysisen_IE
dc.subjectMechanical propertiesen_IE
dc.subjectDistraction osteogenesisen_IE
dc.subjectComposite scaffoldsen_IE
dc.subjectContact forcesen_IE
dc.subjectBoneen_IE
dc.subjectHydroxyapatiteen_IE
dc.subjectRegenerationen_IE
dc.titleComputational modelling of ovine critical-sized tibial defects with implanted scaffolds and prediction of the safety of fixator removalen_IE
dc.typeArticleen_IE
dc.date.updated2017-01-19T17:26:30Z
dc.identifier.doi10.1016/j.jmbbm.2015.01.008
dc.local.publishedsourcehttp://dx.doi.org/10.1016/j.jmbbm.2015.01.008en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|1267872|~|6201984|~|
dc.internal.rssid9137062
dc.local.contactStefan Lohfeld, Mechanical & Biomedical Eng, Engineering Building Eng-1042, Nui Galway. 2963 Email: stefan.lohfeld@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
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