Biomedical Engineering (Scholarly Articles): Recent submissions
Now showing items 61-80 of 128
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Oxidation behaviour of particle reinforced MoSi2 composites at temperatures up to 1700°C. Part II: Initial screening of the oxidation behaviour of MoSi2 composites
(Wiley, 2005-03-01)In the first part of this paper a literature survey on the oxidation behaviour of MoSi2 and MoSi2 composites has been given. The present second part reports about the experimental results from oxidation tests with ... -
Oxidation behaviour of particle reinforced MoSi2 composites at temperatures up to 1700°C
(Wiley, 2005-04-04)The topic Oxidation behaviour of particle reinforced MoSi2 composites at temperatures up to 1700°C is discussed in a three part publication. In the first part of this paper a literature survey on the oxidation ... -
Design and manufacturing of customised maxillofacial prostheses.
(Elsevier, 2003-04-28)Customised implants created by Computer-Assisted Surgery (CAS) techniques and used in maxillofacial reconstruction indicate improved outcomes over conventional techniques. ‘‘Non-functional’’ multistaged procedures are ... -
Oxidation behaviour of particle reinforced MoSi2 composites at temperatures up to 1700 °C, Part I: Literature Review
(Wiley, 2005-02-04)In the first part of this paper the results of a literature review are presented. An overview of the oxidation behaviour in air and in combustion environments of both pure MoSi2 and MoSi2 composites in the temperature range ... -
Mechanical stimulation of bone marrow in situ induces bone formation in trabecular explants
(Springer Verlag, 2014-10-04)Abstract Low magnitude high frequency (LMHF) loading has been shown to have an anabolic effect on trabecular bone in vivo. However, the precise mechanical signal imposed on the bone marrow cells by LMHF loading, which ... -
Experimental mechanical testing of Poly (l-Lactide) (PLLA) to facilitate pre-degradation characteristics for application in cardiovascular stenting
(Elsevier, 2016-07-19)Next-generation stents made from Biodegradable Polymers (BPs) aim to address the long-term risks (i.e. late restenosis and in-stent thrombosis) associated with both Bare Metal Stents and Drug Eluting Stents, whilst aiming ... -
Computational modelling of ovine critical-sized tibial defects with implanted scaffolds and prediction of the safety of fixator removal
(Elsevier, 2015-01-14)Computational model geometries of tibial defects with two types of implanted tissue engineering scaffolds, β-tricalcium phosphate (β-TCP) and poly-ε-caprolactone (PCL)/β-TCP, are constructed from µ-CT scan images of the ... -
The effect of substrate stiffness, thickness, and cross-linking density on osteogenic cell behavior
(Biophysical Society, 2015-04-07)Osteogenic cells respond to mechanical changes in their environment by altering their spread area, morphology, and gene expression profile. In particular, the bulk modulus of the substrate, as well as its microstructure ... -
Primary cilia exist in a small fraction of cells in trabecular bone and marrow
(Springer, 2014-11-15)Primary cilia are potent mechanical and chemical sensory organelles in cells of bone lineage in tissue culture. Cell culture experiments suggest that primary cilia sense fluid flow and this stimulus is translated through ... -
Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes
(Wiley, 2013-12-03)Bone continuously adapts its internal structure to accommodate the functional demands of its mechanical environment. This process is orchestrated by a network of mechanosensitive osteocytes that respond to external ... -
Thermally induced osteocyte damage initiates a remodelling signaling cascade
(Public Library of Science, 2015-03-18)Thermal elevations experienced by bone during orthopaedic procedures, such as cutting and drilling, exothermal reactions from bone cement, and thermal therapies such as tumor ablation, can result in thermal damage leading ... -
Multiscale fluid-structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold
(2015-04)Recent studies have shown that mechanical stimulation, by means of flow perfusion and mechanical compression (or stretching), enhances osteogenic differentiation of mesenchymal stem cells and bone cells within biomaterial ... -
Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures
(Springer Verlag, 2016-06)Recent studies have shown that mechanical stimulation, in the form of fluid perfusion and mechanical compression, can enhance osteogenic differentiation of mesenchymal stem cells and bone cells within tissue engineering ... -
An in vitro bone tissue regeneration strategy combining chondrogenic and vascular priming enhances the mineralization potential of mesenchymal stem cells In vitro while also allowing for vessel formation
(Mary Ann Liebert, 2015-03-03)Chondrogenic priming (CP) of mesenchymal stem cells (MSCs) and coculture of MSCs with human umbilical vein endothelial stem cells (HUVECs) both have been shown to significantly increase the potential for MSCs to undergo ... -
A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone
(Elsevier, 2012-03-20)Bone is an exceptional material that is lightweight for efficient movement but also exhibits excellent strength and stiffness imparted by a composite material of organic proteins and mineral crystals that are intricately ... -
The role of integrin αVβ3 in osteocyte mechanotransduction
(Elsevier, 2014-11-10)Recent in vivo studies have proposed that integrin alpha(v)beta(3) attachments between osteocyte cell processes and the extracellular matrix may facilitate mechanosensation in bone. However the role of these attachments ... -
Differential β3 and β1 integrin expression in bone marrow and cortical bone of estrogen deficient rats
(Wiley, 2015-08-12)Integrin-based (beta(3)) attachments to the extracellular matrix (ECM) on osteocyte cell processes have recently been proposed to play an important role in facilitating osteocyte mechanosensation. However, it is not yet ... -
Investigation of the optimal timing for chondrogenic priming of MSCs to enhance osteogenic differentiation in vitro as a bone tissue engineering strategy
(Wiley, 2013-08-07)Recent in vitro tissue engineering approaches have shown that chondrogenic priming of human bone marrow mesenchymal stem cells (MSCs) can have a positive effect on osteogenesis in vivo. However, whether chondrogenic ... -
A combined experimental-numerical approach for generating statistically equivalent fibre distributions for high strength laminated composite materials
(Elsevier, 2009-11-04)A technique is presented where actual experimental distributions, measured from a high strength carbon fibre composite, are considered in the development of a novel method to generate statistically equivalent fibre ... -
Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation
(Elsevier, 2013-07-18)Osteocytes are terminally differentiated bone cells, derived from osteoblasts, which are vital for regulation of bone formation and resorption. ECM stiffness and cell seeding density have been shown to regulate osteoblast ...