Biomedical Engineering (Scholarly Articles): Recent submissions
Now showing items 41-60 of 128
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Value of an RA qualification in continuous professional development and career progression
(Regulatory Affairs Professionals Society, 2021-04-26)Continuous professional development (CPD) is important for employee personal development and is of strategic value for organizations. Having qualified and knowledgeable personnel can help deploy strategy and yield competitive ... -
A study on the Ishikawa's original basic tools of quality control in South American companies: results from a pilot survey and directions for further research
(Emerald, 2021-03-09)The main purpose of this study is to revisit Dr. Ishikawa s statement: 95% of problems in processes can be accomplished using the 7 Quality Control (QC) tools from his book What is Quality Control? . The authors are ... -
Applying Lean Six Sigma methodology to a pharmaceutical manufacturing facility: A case study
(MDPI, 2021-03-20)This research examines a case study on the implementation of an effective approach to advanced Lean Six Sigma problem-solving within a pharmaceutical manufacturing site that manufactures acetaminophen (paracetamol containing ... -
Exploring the use of operational excellence methodologies in the era of COVID-19: perspectives from leading academics and practitioners
(Emerald, 2021-02-25)Purpose This paper aims to present the results of a study carried out by the authors in the form of research interviews on the topic: “Exploring the use of operational excellence methodologies in the era of COVID-19.” ... -
Pre-culture of mesenchymal stem cells within RGD-modified hyaluronic acid hydrogel improves their resilience to ischaemic conditions
(Elsevier, 2020-03-04)The incorporation of the RGD peptide (arginine-glycine-aspartate) into biomaterials has been proposed to promote cell adhesion to the matrix, which can influence and control cell behaviour and function. While many studies ... -
An actuatable soft reservoir modulates host foreign body response
(American Association for the Advancement of Science, 2019-08-28)The performance of indwelling medical devices that depend on an interface with soft tissue is plagued by complex, unpredictable foreign body responses. Such devices—including breast implants, biosensors, and drug delivery ... -
Estrogen deficiency impairs integrin αvβ3-mediated mechanosensation by osteocytes and alters osteoclastogenic paracrine signalling
(Nature Research (part of Springer Nature), 2019-03-15)The integrin alpha(v)beta(3) has been shown to play an important role in osteocyte mechanotransduction. It has been reported that there are fewer beta(3) integrin-containing cells in osteoporotic bone cells. Osteocytes ... -
A through-process, thermomechanical model for predicting welding-induced microstructure evolution and post-weld high-temperature fatigue response
(Elsevier, 2018-02-11)This paper is concerned with the development of a modelling framework to predict the effects of welding and post-weld heat treatment on thereto-mechanical performance of welded material, as a step towards a design tool for ... -
Primary cilia expression in bone marrow in response to mechanical stimulation in explant bioreactor culture
(AO Research Institute Davos, 2016-07-19)Bone marrow contains a multitude of mechanically sensitive cells that may participate in mechanotransduction. Primary cilia are sensory organelles expressed on mesenchymal stem cells (MSCs), osteoblasts, osteocytes, and ... -
Does making method of alginate hydrogel influence the chondrogenic differentiation of human mesenchymal stem cells?
(Scientific Research Publishing, 2012-10)To overcome cartilage injury, strategies have been developed in the last few years based on tissue engineering to rebuild the defects. Cartilage engineering is principally based on three main biological factors: cells ... -
Chondrogenic induction of mesenchymal stromal/stem cells from Wharton's jelly embedded in alginate hydrogel and without added growth factor: an alternative stem cell source for cartilage tissue engineering
(BioMed Central, 2015-12-30)Background: Due to their intrinsic properties, stem cells are promising tools for new developments in tissue engineering and particularly for cartilage tissue regeneration. Although mesenchymal stromal/stem cells from bone ... -
Mechanical stimulations on human bone marrow mesenchymal stem cells enhance cells differentiation in a three-dimensional layered scaffold
(Wiley, 2017-05-09)Scaffolds laden with stem cells are a promising approach for articular cartilage repair. Investigations have shown that implantation of artificial matrices, growth factors or chondrocytes can stimulate cartilage formation, ... -
A living thick nanofibrous implant bifunctionalized with active growth factor and stem cells for bone regeneration
(Dove Medical Press, 2015-02-04)New-generation implants focus on robust, durable, and rapid tissue regeneration to shorten recovery times and decrease risks of postoperative complications for patients. Herein, we describe a new-generation thick nanofibrous ... -
Electro-spinning of pure collagen nano-fibres – Just an expensive way to make gelatin?
(Elsevier, 2008-03-03)Scaffolds manufactured from biological materials promise better clinical functionality, providing that characteristic features are preserved. Collagen, a prominent biopolymer, is used extensively for tissue engineering ... -
Macromolecular crowding meets tissue engineering by self-ssembly: A paradigm shift in regenerative medicine
(Wiley, 2014-02-06)Advancements in molecular and cell biology have led to the development of cell-based therapies to treat injured or degenerated tissues. [1] The rationale of this concept is that functional regeneration can be achieved ... -
A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction
(Elsevier, 2019-05-15)The limited regenerative capacity of the heart after a myocardial infarct results in remodeling processes that can progress to congestive heart failure (CHF). Several strategies including mechanical stabilization of the ... -
An injectable alginate/extra cellular matrix (ECM) hydrogel towards acellular treatment of heart failure
(Springer Verlag, 2018-12-03)As treatments for myocardial infarction (MI) continue to improve, the population of people suffering from heart failure (HF) is rising significantly. Novel treatment strategies aimed at achieving long-term functional ... -
Advanced Material Catheter (AMCath), a minimally invasive endocardial catheter for the delivery of fast-gelling covalently cross-linked hyaluronic acid hydrogels
(SAGE Publications, 2018-10-25)Injectable hydrogels that aim to mechanically stabilise the weakened left ventricle wall to restore cardiac function or to deliver stem cells in cardiac regenerative therapy have shown promising data. However, the clinical ... -
Investigation of the mechanical interaction of the trabecular core with an external shell using rapid prototype and finite element models
(Elsevier, 2009-04-05)The mechanical properties of vertebral bone have been widely studied with the ultimate goal of improving fracture risk prediction. However, the mechanical interaction between the cortical shell and the trabecular core is ... -
The past, present and future in scaffold-based tendon treatments
(Elsevier, 2015-04)Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent especially among young ...