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Computational investigation of in situ chondrocyte deformation and actin cytoskeleton remodelling under physiological loading
(Elsevier, 2012-12-24)
Previous experimental studies have determined local strain fields for both healthy and degenerate cartilage tissue during mechanical loading. However, the biomechanical response of chondrocytes in situ, in particular the ...
The effect of remodelling and contractility of the actin cytoskeleton on the shear resistance of single cells: a computational and experimental investigation
(The Royal Society Publishing, 2012-07-18)
The biomechanisms that govern the response of chondrocytes to mechanical stimuli are poorly understood. In this study, a series of in vitro tests are performed, in which single chondrocytes are subjected to shear deformation ...
Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open -cell tissue engineering scaffolds
(Elsevier, 2015-09-02)
Scaffolding plays a critical rule in tissue engineering and an appropriate degradation rate and sufficient mechanical integrity are required during degradation and healing of tissue. This paper presents a computational ...
Numerical investigation of the active role of the actin cytoskeleton in the compression resistance of cells
(Elsevier ScienceDirect, 2012-06-21)
Numerous in-vitro studies have established that cells react to their physical environment and to applied mechanical loading. However, the mechanisms underlying such phenomena are poorly understood. Previous modelling of ...
A thermodynamically motivated model for stress-fiber reorganization
(Springer Verlag, 2015-09-04)
We present a model for stress-fiber reorganization and the associated contractility that includes both the kinetics of stress-fiber formation and dissociation as well as the kinetics of stress-fiber remodeling. These ...
Cellular contractility and substrate elasticity: a numerical investigation of the actin cytoskeleton and cell adhesion
(Springer Verlag, 2013-06-18)
Numerous experimental studies have established that cells can sense the stiffness of underlying substrates and have quantified the effect of substrate stiffness on stress fibre formation, focal adhesion area, cell traction, ...
Oxidation behaviour of particle reinforced MoSi2 composites at temperatures up to 1700 °C, Part I: Literature Review
(Wiley, 2005-02-04)
In the first part of this paper the results of a literature review are presented. An overview of the oxidation behaviour in air and in combustion environments of both pure MoSi2 and MoSi2 composites in the temperature range ...
Oxidation behaviour of particle reinforced MoSi2 composites at temperatures up to 1700°C. Part II: Initial screening of the oxidation behaviour of MoSi2 composites
(Wiley, 2005-03-01)
In the first part of this paper a literature survey on the oxidation behaviour of MoSi2 and MoSi2
composites has been given. The present second part reports about the
experimental results from oxidation tests with ...
Evaluation of a multiscale modelling methodology to predict the mechanical properties of PCL/β-TCP sintered scaffold materials
(Springer Verlag, 2014-12-02)
A multiscale modelling methodology to predict the macroscale stiffness of selective laser sintered polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) materials is evaluated. The relationship between a micromechanics-evaluated ...
The effect of grain orientation on fretting fatigue plasticity and life prediction
(Elsevier ScienceDirect, 2014)
A study on crystal and J2J2 plasticity prediction of fretting fatigue is presented, using a microstructure-sensitive fatigue parameter for crystal plasticity crack nucleation and a critical-plane (multiaxial) fatigue ...