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Mechanical stimulation of bone marrow in situ induces bone formation in trabecular explants
(Springer Verlag, 2014-10-04)
Abstract Low magnitude high frequency (LMHF) loading has been shown to have an anabolic effect on trabecular bone in vivo. However, the precise mechanical signal imposed on the bone marrow cells by LMHF loading, which ...
The effect of substrate stiffness, thickness, and cross-linking density on osteogenic cell behavior
(Biophysical Society, 2015-04-07)
Osteogenic cells respond to mechanical changes in their environment by altering their spread area, morphology, and gene expression profile. In particular, the bulk modulus of the substrate, as well as its microstructure ...
Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes
(Wiley, 2013-12-03)
Bone continuously adapts its internal structure to accommodate the
functional demands of its mechanical environment. This process is
orchestrated by a network of mechanosensitive osteocytes that respond to
external ...
Differential β3 and β1 integrin expression in bone marrow and cortical bone of estrogen deficient rats
(Wiley, 2015-08-12)
Integrin-based (beta(3)) attachments to the extracellular matrix (ECM) on osteocyte cell processes have recently been proposed to play an important role in facilitating osteocyte mechanosensation. However, it is not yet ...
Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures
(Springer Verlag, 2016-06)
Recent studies have shown that mechanical stimulation, in the form of fluid perfusion and mechanical compression, can enhance osteogenic differentiation of mesenchymal stem cells and bone cells within tissue engineering ...
Thermally induced osteocyte damage initiates a remodelling signaling cascade
(Public Library of Science, 2015-03-18)
Thermal elevations experienced by bone during orthopaedic procedures, such as cutting and drilling, exothermal reactions from bone cement, and thermal therapies such as tumor ablation, can result in thermal damage leading ...
Effects of in vitro endochondral priming and pre-vascularisation of human MSC cellular aggregates in vivo
(2015)
Introduction: During endochondral ossification, both the production of a cartilage template and the subsequent vascularisation of that template are essential precursors to bone tissue formation. Recent studies have found ...
An in vitro bone tissue regeneration strategy combining chondrogenic and vascular priming enhances the mineralization potential of mesenchymal stem cells In vitro while also allowing for vessel formation
(Mary Ann Liebert, 2015-03-03)
Chondrogenic priming (CP) of mesenchymal stem cells (MSCs) and coculture of MSCs with human umbilical vein endothelial stem cells (HUVECs) both have been shown to significantly increase the potential for MSCs to undergo ...
On the role of the actin cytoskeleton and nucleus in the biomechanical response of spread cells
(Elsevier, 2014-02-11)
Micropipette aspiration (MA) has been used extensively in biomechanical investigations of un-adhered cells suspended in media. In the current study, a custom MA system is developed to aspirate substrate adhered spread ...
Multiscale fluid-structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold
(2015-04)
Recent studies have shown that mechanical stimulation, by means of flow perfusion and mechanical compression (or stretching), enhances osteogenic differentiation of mesenchymal stem cells and bone cells within biomaterial ...