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Single Cyclized Molecule Structure from RAFT Homopolymerization of Multi-vinyl Monomers
(2012)
We explore a kinetically controlled strategy to suppress the gelation in the homopolymerization of multi-vinyl monomers (MVMs) via RAFT polymerization. We report the generation of 3D single cyclized polymer structures from ...
The past, present and future in scaffold-based tendon treatments
(Elsevier, 2015-04)
Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent especially among young ...
Recovery of cardiac function mediated by MSC and interleukin-10 plasmid functionalised scaffold
(2011-11)
Stem cell transplantation has been suggested as a treatment for myocardial infarction, but clinical studies have yet to demonstrate conclusive, positive effects. This may be related to poor survival of the transplanted ...
Electromechanical properties of dried tendon and isoelectrically focused collagen hydrogels
(Elsevier, 2012-08)
Assembling artificial collagenous tissues with structural, functional, and mechanical properties which mimic natural tissues is of vital importance for many tissue engineering applications. While the electro-mechanical ...
A Fluorescently Labeled, Hyperbranched Polymer Synthesized from DE-ATRP for the Detection of DNA Hybridization
(Royal Society of Chemistry, 2012-01)
The early detection of oligonucleotide biomarkers of disease, such as microRNAs, has been established as a fundamental factor in cancer diagnosis. As the levels of these small molecules (microRNAs) in blood have recently ...
Mannosylated Polyethyleneimine-Hyaluronan Nanohybrids for Targeted Gene Delivery to Macrophage-Like Cell Lines
(American Chemical Society, 2012-05-02)
Nonviral gene delivery systems have a number of limitations including low transfection efficiency, specificity, and cytotoxicity, especially when the target cells are macrophages. To address these issues, the hypothesis ...
Single Cyclized Molecule Versus Single Branched Molecule: A Simple and Efficient 3D "Knot" Polymer Structure for Nonviral Gene Delivery
(American Chemical Society, 2012-02-12)
The large research effort focused on enhancing nonviral transfection vectors has clearly demonstrated that their macromolecular structure has a significant effect on their transfection efficacy. The 3D branched polymeric ...
A Biomaterial Approach to Peripheral Nerve Regeneration: Bridging the Peripheral Nerve Gap and Enhancing Functional Recovery
(The Royal Society, 2011-11)
Microsurgical techniques for the treatment of large peripheral nerve injuries (such as the gold standard autograft) and its main clinically approved alternative 'hollow nerve guidance conduits (NGCs)' have a number of ...
Preferential cell response to anisotropic electro-spun fibrous scaffolds under tension-free conditions
(Springer, 2010-11)
Anisotropic alignment of collagen fibres in musculoskeletal tissues is responsible for the resistance to mechanical loading, whilst in cornea is responsible for transparency. Herein, we evaluated the response of tenocytes, ...
DNA Immobilization and Detection on Cellulose Paper using a Surface Grown Cationic Polymer via ATRP
(American Chemical Society, 2012-02-02)
Cationic polymers with various structures have been widely investigated in the areas of medical diagnostics and molecular, biology because of their unique binding properties and capability to interact with biological ...