Browsing Biomedical Engineering (Scholarly Articles) by Author "|~|1267872|~|"
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Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes
Vaughan, Ted J.; Verbruggen, Stefaan W.; McNamara, Laoise M. (Wiley, 2013-12-03)Bone continuously adapts its internal structure to accommodate the functional demands of its mechanical environment. This process is orchestrated by a network of mechanosensitive osteocytes that respond to external ... -
Improving the finite element model accuracy of tissue engineered scaffolds produced by selective laser sintering
Lohfeld, Stefan; Cahill, Senan; Doyle, Heather; McHugh, Peter E. (Springer Verlag, 2015-01-13)In bone tissue engineering, both geometrical and mechanical properties of a scaffold play a major part in the success of the treatment. The mechanical stresses and strains that act on cells on a scaffold in a physiological ... -
Investigation of the optimal timing for chondrogenic priming of MSCs to enhance osteogenic differentiation in vitro as a bone tissue engineering strategy
Freeman, Fiona E.; Haugh, Matthew G.; McNamara, Laoise M. (Wiley, 2013-08-07)Recent in vitro tissue engineering approaches have shown that chondrogenic priming of human bone marrow mesenchymal stem cells (MSCs) can have a positive effect on osteogenesis in vivo. However, whether chondrogenic ... -
Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation
Mullen, Conleth A.; Haugh, Matthew G.; Schaffler, M. B.; Majeska, R. J.; McNamara, Laoise M. (Elsevier, 2013-07-18)Osteocytes are terminally differentiated bone cells, derived from osteoblasts, which are vital for regulation of bone formation and resorption. ECM stiffness and cell seeding density have been shown to regulate osteoblast ...