Browsing Biomedical Engineering (Scholarly Articles) by Author "Mullen, Conleth A."
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The effect of substrate stiffness, thickness, and cross-linking density on osteogenic cell behavior
Mullen, Conleth A.; Vaughan, Ted J.; Billiar, Kristen L.; McNamara, Laoise M. (Biophysical Society, 2015-04-07)Osteogenic cells respond to mechanical changes in their environment by altering their spread area, morphology, and gene expression profile. In particular, the bulk modulus of the substrate, as well as its microstructure ... -
Osteocyte differentiation and the formation of an interconnected cellular network in vitro
Mc Garrigle, M.J.; Mullen, Conleth A.; Haugh, Matthew G.; Voisin, Muriel C.; McNamara, Laoise M. (AO Research Institute Davos, 2016-05-26)Extracellular matrix (ECM) stiffness and cell density can regulate osteoblast differentiation in two dimensional environments. However, it is not yet known how osteoblast-osteocyte differentiation is regulated within a 3D ... -
Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation
Mullen, Conleth A.; Haugh, Matthew G.; Schaffler, M. B.; Majeska, R. J.; McNamara, Laoise M. (Elsevier, 2013-07-18)Osteocytes are terminally differentiated bone cells, derived from osteoblasts, which are vital for regulation of bone formation and resorption. ECM stiffness and cell seeding density have been shown to regulate osteoblast ...