Browsing Biomedical Engineering (Scholarly Articles) by Title
Now showing items 83-102 of 128
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A method to fabricate small features on scaffolds for tissue engineering via selective laser sintering
(2010)Purpose:Selective laser sintering (SLS) is a rapid prototyping technique applied to produce tissue-engineering scaffolds from powder materials. The standard scanning technique, however, often produces struts of extensive ... -
Micro-scale testing and micromechanical modelling for high cycle fatigue for CoCr stent material
(Elsevier ScienceDirect, 2015-02-20)This paper presents a framework of experimental testing and crystal plasticity micromechanics for high cycle fatigue (HCF) of micro-scale L605 CoCr stent material. Micro-scale specimens, representative of stent struts, are ... -
Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open -cell tissue engineering scaffolds
(Elsevier, 2015-09-02)Scaffolding plays a critical rule in tissue engineering and an appropriate degradation rate and sufficient mechanical integrity are required during degradation and healing of tissue. This paper presents a computational ... -
Motivations, barriers and readiness factors for Quality 4.0 implementation: an exploratory study
(Emerald, 2021-01-22)Purpose Quality 4.0 is the new buzzword among quality professionals. There has been no empirical study of Quality 4.0 yet. Hence, the purpose of this paper is to investigate what are the motivations, barriers and readiness ... -
Multiscale fluid-structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold
(2015-04)Recent studies have shown that mechanical stimulation, by means of flow perfusion and mechanical compression (or stretching), enhances osteogenic differentiation of mesenchymal stem cells and bone cells within biomaterial ... -
Numerical investigation of the active role of the actin cytoskeleton in the compression resistance of cells
(Elsevier ScienceDirect, 2012-06-21)Numerous in-vitro studies have established that cells react to their physical environment and to applied mechanical loading. However, the mechanisms underlying such phenomena are poorly understood. Previous modelling of ... -
On the role of the actin cytoskeleton and nucleus in the biomechanical response of spread cells
(Elsevier, 2014-02-11)Micropipette aspiration (MA) has been used extensively in biomechanical investigations of un-adhered cells suspended in media. In the current study, a custom MA system is developed to aspirate substrate adhered spread ... -
Osteocyte differentiation and the formation of an interconnected cellular network in vitro
(AO Research Institute Davos, 2016-05-26)Extracellular matrix (ECM) stiffness and cell density can regulate osteoblast differentiation in two dimensional environments. However, it is not yet known how osteoblast-osteocyte differentiation is regulated within a 3D ... -
Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation
(Elsevier, 2013-07-18)Osteocytes are terminally differentiated bone cells, derived from osteoblasts, which are vital for regulation of bone formation and resorption. ECM stiffness and cell seeding density have been shown to regulate osteoblast ... -
Osteogenic differentiation of mesenchymal stem cells is regulated by osteocyte and osteoblast cells in a simplified bone niche
(AO Research Institute Davos, 2012)Mesenchymal stem cells (MSCs) within their native environment of the stem cell niche in bone receive biochemical stimuli from surrounding cells. These stimuli likely influence how MSCs differentiate to become bone precursors. ... -
Oxidation behaviour of particle reinforced MoSi2 composites at temperatures up to 1700 °C, Part I: Literature Review
(Wiley, 2005-02-04)In the first part of this paper the results of a literature review are presented. An overview of the oxidation behaviour in air and in combustion environments of both pure MoSi2 and MoSi2 composites in the temperature range ... -
Oxidation behaviour of particle reinforced MoSi2 composites at temperatures up to 1700°C
(Wiley, 2005-04-04)The topic Oxidation behaviour of particle reinforced MoSi2 composites at temperatures up to 1700°C is discussed in a three part publication. In the first part of this paper a literature survey on the oxidation ... -
Oxidation behaviour of particle reinforced MoSi2 composites at temperatures up to 1700°C. Part II: Initial screening of the oxidation behaviour of MoSi2 composites
(Wiley, 2005-03-01)In the first part of this paper a literature survey on the oxidation behaviour of MoSi2 and MoSi2 composites has been given. The present second part reports about the experimental results from oxidation tests with ... -
The past, present and future in scaffold-based tendon treatments
(Elsevier, 2015-04)Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent especially among young ... -
A physical corrosion model for bioabsorbable metal stents
(2014)Absorbable metal stents (AMSs) are an emerging technology in the treatment of heart disease. Computational modelling of AMS performance will facilitate the development of this technology. In this study a physical corrosion ... -
Potential-based and non-potential-based cohesive zone formulations under mixed-mode separation and over-closure. Part I: Theoretical Analysis
(2013)This paper presents a thorough analysis of potential-based and non-potential-based cohesive zone models (CZMs) under conditions of mixed-mode separation and mixed-mode over-closure. Problems are identified with the well ... -
Potential-based and non-potential-based cohesive zone formulations under mixed-mode separation and over-closure. Part II: Finite element applications
(2013)This paper, the second of two parts, presents three novel finite element case studies to demonstrate the importance of normal-tangential coupling in cohesive zone models (CZMs) for the prediction of mixed-mode interface ... -
Pre-culture of mesenchymal stem cells within RGD-modified hyaluronic acid hydrogel improves their resilience to ischaemic conditions
(Elsevier, 2020-03-04)The incorporation of the RGD peptide (arginine-glycine-aspartate) into biomaterials has been proposed to promote cell adhesion to the matrix, which can influence and control cell behaviour and function. While many studies ... -
Preferential cell response to anisotropic electro-spun fibrous scaffolds under tension-free conditions
(Springer, 2010-11)Anisotropic alignment of collagen fibres in musculoskeletal tissues is responsible for the resistance to mechanical loading, whilst in cornea is responsible for transparency. Herein, we evaluated the response of tenocytes, ... -
Primary cilia exist in a small fraction of cells in trabecular bone and marrow
(Springer, 2014-11-15)Primary cilia are potent mechanical and chemical sensory organelles in cells of bone lineage in tissue culture. Cell culture experiments suggest that primary cilia sense fluid flow and this stimulus is translated through ...