Browsing Biomedical Engineering (Scholarly Articles) by Title
Now showing items 65-84 of 128
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Improving the finite element model accuracy of tissue engineered scaffolds produced by selective laser sintering
(Springer Verlag, 2015-01-13)In bone tissue engineering, both geometrical and mechanical properties of a scaffold play a major part in the success of the treatment. The mechanical stresses and strains that act on cells on a scaffold in a physiological ... -
An in vitro bone tissue regeneration strategy combining chondrogenic and vascular priming enhances the mineralization potential of mesenchymal stem cells In vitro while also allowing for vessel formation
(Mary Ann Liebert, 2015-03-03)Chondrogenic priming (CP) of mesenchymal stem cells (MSCs) and coculture of MSCs with human umbilical vein endothelial stem cells (HUVECs) both have been shown to significantly increase the potential for MSCs to undergo ... -
Industry 4.0 benefits, challenges and critical success factors: a comparative analysis through the lens of resource dependence theory across continents and economies
(Emerald, 2023-06-21)The study ranks benefits, challenges and CSFs across economies and continents. Further, the benefit of Industry 4.0 helping to achieve organizational efficiency and agility differed across the developing and developed ... -
An injectable alginate/extra cellular matrix (ECM) hydrogel towards acellular treatment of heart failure
(Springer Verlag, 2018-12-03)As treatments for myocardial infarction (MI) continue to improve, the population of people suffering from heart failure (HF) is rising significantly. Novel treatment strategies aimed at achieving long-term functional ... -
An investigation of the inelastic behaviour of trabecular bone during the press-fit implantation of a tibial component in total knee arthroplasty
(Institute of Physics and Engineering in Medicine by Elsevier Ltd., 2013)The stress distribution and plastic deformation of peri-prosthetic trabecular bone during press-fit tibial component implantation in total knee arthroplasty is investigated using experimental and finite element techniques. ... -
Investigation of the mechanical interaction of the trabecular core with an external shell using rapid prototype and finite element models
(Elsevier, 2009-04-05)The mechanical properties of vertebral bone have been widely studied with the ultimate goal of improving fracture risk prediction. However, the mechanical interaction between the cortical shell and the trabecular core is ... -
Investigation of the optimal timing for chondrogenic priming of MSCs to enhance osteogenic differentiation in vitro as a bone tissue engineering strategy
(Wiley, 2013-08-07)Recent in vitro tissue engineering approaches have shown that chondrogenic priming of human bone marrow mesenchymal stem cells (MSCs) can have a positive effect on osteogenesis in vivo. However, whether chondrogenic ... -
The lack of Ireland’s assisted human reproduction (AHR) regulation viewed under the lens of the patient’s experience
(MDPI, 2022-08-03)Assisted Human Reproduction (AHR) treatment is unregulated in Ireland, although it is practised there. Within Europe, Ireland is one of the only European countries without any form of AHR-specific regulation. This study ... -
Leading the transformation: Agile success factors in an Irish manufacturing company
(Taylor & Francis, 2023-06-01)This study aims to assess the challenges and critical success factors for agile transformation in an Irish manufacturing organisation. Mixed-methods approaches were used to collect data for this study. A quantitative ... -
Lean implementation: analysis of individual-level factors in a biopharmaceutical organisation
(Emerald, 2022-07-20)Purpose An understanding of the motivation of individual employees to adopt lean practices is fundamental to successful lean implementation. This study aims to investigate the adoption of lean practices and provides an ... -
A living thick nanofibrous implant bifunctionalized with active growth factor and stem cells for bone regeneration
(Dove Medical Press, 2015-02-04)New-generation implants focus on robust, durable, and rapid tissue regeneration to shorten recovery times and decrease risks of postoperative complications for patients. Herein, we describe a new-generation thick nanofibrous ... -
Macromolecular crowding meets tissue engineering by self-ssembly: A paradigm shift in regenerative medicine
(Wiley, 2014-02-06)Advancements in molecular and cell biology have led to the development of cell-based therapies to treat injured or degenerated tissues. [1] The rationale of this concept is that functional regeneration can be achieved ... -
Managing engineering change within the paradigm of product llfecycle management
(MDPI, 2022-09-03)Managing change in organizations is a laborious task that consumes value added time in various segments of the product lifecycle including design and development, production, delivery, and product disposition. Product ... -
Mannosylated Polyethyleneimine-Hyaluronan Nanohybrids for Targeted Gene Delivery to Macrophage-Like Cell Lines
(American Chemical Society, 2012-05-02)Nonviral gene delivery systems have a number of limitations including low transfection efficiency, specificity, and cytotoxicity, especially when the target cells are macrophages. To address these issues, the hypothesis ... -
Manufacturing control system development for an in vitro diagnostic product platform
(MDPI, 2021-05-31)The current in vitro diagnostic design process is a combination of methods from engineering disciplines and from government regulatory agencies. The goal of design processes that have been developed is to ensure that a new ... -
Mechanical stimulation of bone marrow in situ induces bone formation in trabecular explants
(Springer Verlag, 2014-10-04)Abstract Low magnitude high frequency (LMHF) loading has been shown to have an anabolic effect on trabecular bone in vivo. However, the precise mechanical signal imposed on the bone marrow cells by LMHF loading, which ... -
Mechanical stimulations on human bone marrow mesenchymal stem cells enhance cells differentiation in a three-dimensional layered scaffold
(Wiley, 2017-05-09)Scaffolds laden with stem cells are a promising approach for articular cartilage repair. Investigations have shown that implantation of artificial matrices, growth factors or chondrocytes can stimulate cartilage formation, ... -
Mechanisms of osteocyte stimulation in osteoporosis
(Elsevier, 2016-05-10)Experimental studies have shown that primary osteoporosis' caused by oestrogen deficiency results in localised alterations in bone tissue properties and mineral composition. Additionally, changes to the lacunar-canalicular ... -
A method to fabricate small features on scaffolds for tissue engineering via selective laser sintering
(2010)Purpose:Selective laser sintering (SLS) is a rapid prototyping technique applied to produce tissue-engineering scaffolds from powder materials. The standard scanning technique, however, often produces struts of extensive ... -
Micro-scale testing and micromechanical modelling for high cycle fatigue for CoCr stent material
(Elsevier ScienceDirect, 2015-02-20)This paper presents a framework of experimental testing and crystal plasticity micromechanics for high cycle fatigue (HCF) of micro-scale L605 CoCr stent material. Micro-scale specimens, representative of stent struts, are ...