Browsing Biomedical Engineering (Scholarly Articles) by Title
Now showing items 41-60 of 128
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Estrogen deficiency impairs integrin αvβ3-mediated mechanosensation by osteocytes and alters osteoclastogenic paracrine signalling
(Nature Research (part of Springer Nature), 2019-03-15)The integrin alpha(v)beta(3) has been shown to play an important role in osteocyte mechanotransduction. It has been reported that there are fewer beta(3) integrin-containing cells in osteoporotic bone cells. Osteocytes ... -
Evaluating the effect of increasing ceramic content on the mechanical properties, material microstructure and degradation of selective laser sintered PCL/b-TCP materials
(Elsevier, 2015-06-06)Orthopaedic scaffold materials were fabricated from polycaprolactone (PCL) and composite PCL β-tricalcium phosphate (PCL/β-TCP) powders using selective laser sintering (SLS). Incorporating β-TCP particles is ... -
Evaluation of a multiscale modelling methodology to predict the mechanical properties of PCL/β-TCP sintered scaffold materials
(Springer Verlag, 2014-12-02)A multiscale modelling methodology to predict the macroscale stiffness of selective laser sintered polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) materials is evaluated. The relationship between a micromechanics-evaluated ... -
An evaluation of Lean and Six Sigma methodologies in the national health service
(Emerald, 2021-10-18)The purpose of this paper is to conduct an empirical study derived from previous literature from the perspective of benefits, tools and techniques, Continuous Improvement (CI) and Quality Improvement (QI) methodologies, ... -
The evolution and future of lean Six Sigma 4.0
(Emerald, 2022-05-24)Purpose This purpose of this study is to provide an overview of the current state of research on Lean Six Sigma (LSS) and Industry 4.0 and the key aspects of the relationships between them. The research analyses LSS's ... -
The evolution of Ireland’s medical device cluster and its future direction
(MDPI, 2022-08-16)Ireland has developed a highly successful medical device cluster. Most of the industry started from USA multinationals that moved to Ireland in the 1990s. An ecosystem has now developed with strong linkages between ... -
An experimental and computational investigation of the post-yield behaviour of trabecular bone during vertebral device subsidence
(Springer-Verlag, 2013)Interbody fusion device subsidence has been reported clinically. An enhanced understanding of the mechanical behaviour of the surrounding bone would allow for accurate predictions of vertebral subsidence. The multiaxial ... -
Experimental and computational investigation of the role of stress fiber contractility in the resistance of osteoblasts to compression
(2013)The mechanical behavior of the actin cytoskeleton has previously been investigated using both experimental and computational techniques. However, these investigations have not elucidated the role the cytoskeleton plays in ... -
Experimental and numerical characterisation of the elasto-plastic properties of bovine trabecular bone and a trabecular bone analogue
(2012)The inelastic pressure dependent compressive behaviour of bovine trabecular bone is investigated through experimental and computational analysis. Two loading configurations are implemented, uniaxial and confined compression, ... -
Experimental mechanical testing of Poly (l-Lactide) (PLLA) to facilitate pre-degradation characteristics for application in cardiovascular stenting
(Elsevier, 2016-07-19)Next-generation stents made from Biodegradable Polymers (BPs) aim to address the long-term risks (i.e. late restenosis and in-stent thrombosis) associated with both Bare Metal Stents and Drug Eluting Stents, whilst aiming ... -
An exploration of organizational readiness factors for Quality 4.0: an intercontinental study and future research directions
(Emerald, 2021-12-31)Quality 4.0 incorporates the role of automation and digitization and provides competitive advantage for organizations by enhancing customer experience and increase profitability. The purpose of this study is to critically ... -
Exploring the use of operational excellence methodologies in the era of COVID-19: perspectives from leading academics and practitioners
(Emerald, 2021-02-25)Purpose This paper aims to present the results of a study carried out by the authors in the form of research interviews on the topic: “Exploring the use of operational excellence methodologies in the era of COVID-19.” ... -
Fabrication, mechanical and in vivo performance of polycaprolactone/tricalcium phosphate composite scaffolds
(2012)This paper explores the use of selective laser sintering (SLS) for the generation of bone tissue engineering scaffolds from polycaprolactone (PCL) and PCL/tricalcium phosphate (TCP). Different scaffold designs are generated, ... -
Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach
(Springer Verlag, 2013-04-09)Osteocytes are believed to be the primary sensor of mechanical stimuli in bone, which orchestrate osteoblasts and osteoclasts to adapt bone structure and composition to meet physiological loading demands. Experimental ... -
A Fluorescently Labeled, Hyperbranched Polymer Synthesized from DE-ATRP for the Detection of DNA Hybridization
(Royal Society of Chemistry, 2012-01)The early detection of oligonucleotide biomarkers of disease, such as microRNAs, has been established as a fundamental factor in cancer diagnosis. As the levels of these small molecules (microRNAs) in blood have recently ... -
How do the technological capability and strategic flexibility of an organization impact its successful implementation of Industry 4.0? A qualitative viewpoint
(Emerald, 2022-04-18)Purpose Industry 4.0 (I 4.0) consists of numerous digital technologies applied in organizations strategically to add value to the customer. Different organizations have varying degrees of technological capability and ... -
How does performance vary between early and late adopters of Industry 4.0? A qualitative viewpoint
(Emerald, 2021-10-12)Purpose Industry 4.0 is a new trend among organizations. Some organizations have been early adopters or later adopters of Industry 4.0. The purpose of this paper is to investigate how performance effects vary between early ... -
Hyperbranched PEGmethacrylate linear pDMAEMA block copolymer as an efficient non-viral gene delivery vector
(Elsevier, 2012-06-02)A unique hyperbranched polymeric system with a linear poly-2-dimethylaminoethyl methacrylate (pDMAEMA) block and a hyperbranched polyethylene glycol methyl ether methacrylate (PEGMEMA) and ethylene dimethacrylate (EGDMA) ... -
The impact of Healthcare 4.0 on the healthcare service quality: A systematic literature review
(Taylor & Francis, 2022-03-24)Healthcare 4.0 is inspired by Industry 4.0 and its application has resulted in a paradigmatic shift in the field of healthcare. However, the impact of this digital revolution in the healthcare system on healthcare service ... -
The impact of Industry 4.0 on the medical device regulatory product life cycle compliance
(MDPI, 2022-11-07)The fourth industrial revolution, also referred to as Industry 4.0, has resulted in many changes within the MedTech Industry. The MedTech industry is changing from interconnected manufacturing systems using cyber-physical ...